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| Effect of shortterm continuous subcutaneous insulin infusion on the level of lactate dehydrogenase in newly diagnosed type 2 diabetic mellitus |
| ZHANG Cai-Li, Dong Si-Jing, Ye Jing-Jing, et al |
| Department of Endocrinology,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu 212001,China |
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Abstract Objective: To observe the level of serum lactate dehydrogenase（LDH）and to observe the effect of shortterm continuous subcutaneous insulin infusion(CSII) on LDH in newly diagnosed T2DM, and to investigate the association between insulin resistance and LDH. Methods: Thirtysix cases as NGT group and 37 newly diagnosed T2DM patients were involved in this study．The newly diagnosed T2DM patients were treated with CSII for 2 week．Before and after CSII therapy, 75 g oral glucose tolerance test(OGTT) were performed.The level of plasma glucose and insulin were examined respectively, serum LDH and other items were also measured. Results: ① Serum LDH levels in the T2DM group（177.9±43.01)U/L were higher than the NGT group(161.7±19.41） U/L (t=2.130，P<0.05). ② In the T2DM group, there was a significant decrease in fasting plasma glucose (FPG)and 2 h plasma glucose after glucose overload (2hPG) (P <0.01), a significant decrease in homeostasis model assessment for insulin resistance (HOMAIR) values \[2.00(1.35～2.61）vs 1.30(0.91～1.80) \],△INS30/△G30 and △INS120/△G120 were increased markedly\[（1.11±0.95） vs(2.25±2.14)，(1.22±1.14) vs (3.57±3.06)\](P <0.01),serum LDH concentrations were significantly decreased (t=2.397，P<0.05) after CSII treatment for 2 weeks. ③ In the T2DM group, serum LDH levels positively correlated with HOMAIR(r=0.359，P<0.05) . ④ The multiple regression analysis showed that HOMAIR was an independent related factor in the influence of the LDH concentrations. Conclusion: In the T2DM group insulin resistance and islet βcell function were improved and serum LDH concentrations were significantly decreased after two weeks CSII treatment. The levels of LDH were positively associated with insulin resistance.
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Received: 08 August 2012
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2012, Vol. 22 
