Abstract：[Abstract] Objective: To investigate the changes of nasal secretion levels of IL-17A after nasal provocation in allergic rhinitis patients. Methods: The nasal secretion levels of IL-17A was measured by using BDTM Cytometric Bead Array in patients with allergic rhinitis (n=20) compared with those of healthy control subjects (n=20) after using mite nasal provocation. Result： There were significant differences in nasal secretion level of IL-17A between control group and allergic rhinitis patients′ group after nasal provocation 15 minutes, 1 hour, 6 hours (P＜0.05, respectively), however before nasal provocation there were no differences. However there were no differences between patients with allergic rhinitis and control group after nasal provocation 24 hours(P＞0.05). Conclusion: The high expression of nasal secretion levels of IL-17A in the allergic rhinitis patients indicated that IL-17A may be an etiology of allergic rhinitis.
基金资助:
江苏大学临床医学科技发展基金资助项目（JLY2010145）
作者简介: 黄秋生（1966—），男，江苏姜堰人，副主任医师，主要从事耳鼻咽喉疾病临床研究。
引用本文:
黄秋生，陆汉强，田数越，戎彩霞. 鼻腔激发试验对变应性鼻炎患者鼻腔分泌物[J]. 江苏大学学报:医学版, 2012, 22(6): 527-529.
HUANG Qiu-sheng, LU Han-qiang, TIAN Shu-yue, RONG Cai-xia. Expression and significance of nasal IL17A in allergic rhinitis patient after nasal provocation. Journal of Jiangsu University(Medicine Edition), 2012, 22(6): 527-529.
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