Abstract：Objective: To investigate the relationship between the expression of survivin and Caspase-3 protein and the biological behaviors of esophageal precancerosis and cancer tissue. Methods: The expressions of survivin and Caspase-3 proteins in 63 esophageal cancer specimens,86 atypical hyperplasia specimen（include light，moderate and high grade hyperplasia）,and 40 normal esophageal mucous specimens,were investigated with S-P immunohistochemical technique，and their correlation with pathologic characteristic，and clinical stages of esophageal cancer were analyzed. Results: The positive expression rate of survivin protein showed higher trend（rs=0.732，P＜0.01）, while,that of Caspase-3 protein showed lower trend（rs=－0.687，P＜0.05）,from normal esophageal mucous,to light，moderate and high grade hyperplasia ,and to esophageal cancer.In esophageal cancer tissue,the expression of survivin proteins was positively correlated with the lymph node metastasis and clinical stages（P＜0.01）,and that of Caspase3 protein was positively correlated with the degree of differentiation(P＜0.01）. Moreover,there was a negative association between the survivin and Caspase3 protein expression(r=－0.897,P＜0.01). Conclusion: The expression of survivin and Caspase-3 may be significantly related to the occurrence and progression of esophageal carcinoma,and helpful in predicting the biological behavior and prognosis of esophageal cancer.
收稿日期: 2014-05-19
作者简介: 周正斌（1970—），男，江苏泰兴人，副主任医师，主要从事消化道肿瘤的临床诊治。
引用本文:
周正斌, 周瑞, 黄震, 曹鹏, 成宏伟. 生存素和Caspase-3蛋白在食管癌前病变及癌组织中的表达及意义[J]. 江苏大学学报:医学版, 2014, 24(04): 342-345.
ZHOU Zheng-Bin, ZHOU Rui, HUANG Zhen, CAO Peng, CHENG Hong-Wei. Expression and significance of survivin and Caspase-3 protein in esophageal precancerosis and cancer tissue. Journal of Jiangsu University(Medicine Edition), 2014, 24(04): 342-345.
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2014, Vol. 24 
