Analysis of correlation between peripheral blood inflammatory markers and the number of significant intracranial atherosclerotic stenosis in elderly patients with acute ischemic stroke
HE Yue, YANG Yi, XU Yuhao, YU Ming
(Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001, China)
Abstract:Abstract]Objective: To detect the changes of inflammatory markers in peripheral blood of elderly patients with acute ischemic stroke(AIS) and analyze their correlation with the number of significant atherosclerotic stenosis(SAS) in the brain.Methods: Patients elder than 60 years with AIS of large artery atherosclerosis and small artery occlusion subtypes hospitalized in Department of Neurology, Affiliated Hospital of Jiangsu University from August 1st, 2021 to December 31th, 2021 were consecutively enrolled in the study. Biochemical indicators were tested by laboratory examination. Peripheral inflammatory indices were collected via routine blood tests, including leukocyte count, neutrophil count, monocyte count, lymphocyte count, and neutrophiltolymphocyte ratio(NLR). Intracranial SAS was evaluated by magnetic resonance angiography(MRA), which was defined as ≥50% stenosis or occlusion. The subjects were divided into three groups based on the number of intracranial SAS: no SAS(n=77), single SAS(n=45) and multiple(≥2) SAS group(n=33); and the clinical characteristics including biochemical indicators and inflammatory markers were compared among the three groups. Multivariate logistic regression was used to analyze the correlation between the number of intracranial SAS and inflammatory markers. According to the most severe stenosis of intracranial SAS, 78 subjects with SAS were divided into 3 groups: moderate stenosis group(n=23), severe stenosis group(n=17) and occlusion group(n=38). Inflammatory markers of three groups were compared. Spearman rank correlation was used to analyse the correlation between inflammatory indexes and the number of intracranial SAS. Results: Compared with the nonSAS and/or singlevessel SAS group, the age, white blood cell count, neutrophil count and NLR in the multivessel SAS group were significantly increased(all P<0.05). Multivariate logistic regression analysis showed that the number of intracranial SAS was independently correlated with high white blood cell count, high and medium neutrophil count, and high NLR(all P<0.05). There was no significant difference in the inflammatory indexes between the moderate stenosis, severe stenosis and occlusion groups(all P>0.05). The results of Spearman correlation analysis showed that white blood cell count and neutrophil count were weakly correlated with the number of intracranial SAS(r=0.255, P=0.024; r=0.319, P=0.004).Conclusion: Peripheral blood inflammatory indicators in elderly patients with AIS showed increased white blood cell count, neutrophil count and NLR, which were weakly correlated with the number of intracranial SAS.
何悦, 杨溢, 徐宇浩,等.. 老年急性缺血性卒中患者外周血炎性指标与颅内显著动脉粥样硬化狭窄数量相关性分析[J]. 江苏大学学报:医学版, 2022, 32(05): 403-408,414.
HE Yue, YANG Yi, XU Yuhao, YU Ming. Analysis of correlation between peripheral blood inflammatory markers and the number of significant intracranial atherosclerotic stenosis in elderly patients with acute ischemic stroke. Journal of Jiangsu University(Medicine Edition), 2022, 32(05): 403-408,414.
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