SATB2在结直肠腺癌肝转移中的表达及其诊断价值

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摘要目的: 探讨富含AT序列特异性结合蛋白2(special AT-rich sequence-binding protein 2，SATB2)在结直肠腺癌中的表达及其联合检测细胞角蛋白20(cytokeratin 20，CK20)、同源异型框转录因子-2(caudal-related homeodomain transcription 2，CDX2)在结直肠腺癌肝转移中的诊断价值。方法: 应用免疫组织化学法检测100例结直肠腺癌及234例其他类型腺癌中SATB2的表达，同时检测179例肝内5种不同类型腺癌组织中SATB2、CK20及CDX2的表达。分析SATB2、CK20和CDX2灵敏度、特异度及准确度。结果：结直肠腺癌中SATB2阳性表达率(89%)明显高于其他类型腺癌阳性表达率(1.28%， χ2=270.107，P<0.001)。肝癌组织中来源于结直肠腺癌转移者SATB2阳性表达率为84%，非结直肠腺癌转移者SATB2阳性率仅为2.33%。表达的灵敏度、特异度及准确度：SATB2为84.00%、97.67%、93.85%；CK20为76.00%、77.52%、77.09%；CDX2为98.00%、67.44%、75.98%。结论： SATB2在结直肠腺癌中阳性表达率高，其联合CK20、CDX2检测可鉴别诊断结直肠腺癌肝转移。

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关键词 ：富含AT序列特异性结合蛋白2, 细胞角蛋白20, 同源异型框转录因子-2, 结直肠腺癌, 肝转移

Abstract：Objective: To investigate the diagnostic and differential value of special AT-rich sequencebinding protein 2(SATB2) in colorectal adenocarcinoma and combined detection of SATB2 with cytokeratin20 (CK20) and caudalrelated homeodomain transcription 2 (CDX2) in hepatic metastasis of colorectal adenocarcinoma. Methods: Immunohistochemical staining was used to detect the expression of SATB2 in 100 cases of colorectal adenocarcinoma and 234 cases of other types of adenocarcinoma; and the expression of SATB2, CK20 and CDX2 in 5 different types of 179 cases adenocarcinoma tissues was detected. The sensitivity, specificity and accuracy of SATB2, CK20 and CDX2 were analyzed, respectively. Results: The positive expression rate of SATB2 in colorectal adenocarcinoma (89%) was significantly higher than that in other types of adenocarcinoma(1.28%,χ2=270.107,P<0.001). The positive expression rate of SATB2 in liver cancer tissues derived from colorectal adenocarcinoma metastasis was 84.00%, while only 2.33% in patients with noncolorectal adenocarcinoma metastasis. The expression sensitivity, specificity and accuracy were as follows: SATB2 was 84.00%, 97.67% and 93.85%; CK20 was 76.00%, 77.52% and 77.09%; CDX2 was 98.00%, 67.44% and 75.98%. Conclusion: The positive expression rate of SATB2 in colorectal adenocarcinoma was high. Its combination with CK20 and CDX2 could be used to differentiate and diagnose liver metastasis of colorectal adenocarcinoma.

收稿日期: 2019-05-06

基金资助:

国家自然科学基金资助项目(81273124)

通讯作者: 陆荣柱(通讯作者)，教授，E-mail:lurz@mail.ujs.edu.cn

作者简介: 杨奇(1979—)，男，江苏镇江人，副主任医师，主要从事胃肠道肿瘤的研究；

引用本文:

杨奇1，2，陆荣柱1，吴婷3，陈淼3. SATB2在结直肠腺癌肝转移中的表达及其诊断价值[J]. 江苏大学学报:医学版, 2019, 29(05): 410-413,424. YANG Qi1,2, LU Rong-zhu1, WU Ting3, CHEN Miao3.
Expression of SATB2 in liver metastasis from colorectal adenocarcinoma and its diagnosis value. Journal of Jiangsu University(Medicine Edition), 2019, 29(05): 410-413,424.

链接本文:

http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2019/V29/I05/410

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