Abstract：Objective:To explore the significance of PIK3R1 and its encoded protein p85α in squamous cell carcinoma of the cervix(SCC). Methods: HE staining was used to observe the morphology of SCC and benign cervix. The expression of p85α protein in SCC tissues and benign cervix tissues was detected by immunohistochemistry(IHC). The correlation between p85α expression and clinical parameters in SCC was analyzed. Realtime quantitative PCR was used to detect the expression levels of PIK3R1 and PTEN in SCC tissues. Results: The expression levels of p85α protein in SCC was significantly less than that in benign cervix (P<0.01), the expression of p85α protein in advanced cancer patients was lower than that of early tumor tissues both in metastatic tumor tissues(P<0.05). Expression levels of both PIK3R1 and PTEN were decreased in SCC tissues compared with benign cervix. There had a moderate correlation between expression of PIK3R1 and PTEN(r<0.567, P=0.011). Conclusion: PIK3R1 gene and its encoded protein p85α may play a key role in tumor suppression of SCC.
收稿日期: 2018-03-31
基金资助: 镇江市社会发展项目(SH2017013，SH2017020
通讯作者:
陈霞(通讯作者)，主治医师，E-mail：chenxia_0511 @126.com
作者简介: 杨佩芳(1965—)，女，博士，主任医师；
引用本文:
杨佩芳， 丁小星， 于骏， 陈霞. PIK3R1基因及其编码蛋白在宫颈鳞癌中的表达及临床意义[J]. 江苏大学学报:医学版, 2018, 28(05): 423-426,436.
YANG Pei-fang, DING Xiao-xing, YU Jun, CHEN Xia. The expression of PIK3R1 and its encoded protein in squamous cell
carcinoma of the cervix and its clinical value
. Journal of Jiangsu University(Medicine Edition), 2018, 28(05): 423-426,436.
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