Abstract：Objective: To investigate the changes of hippocampal volume and inferior vena cava in patients with first-episode obsessive-compulsive disorder, and to analyze the potential relationship between them. Methods: Sixty first-episode obsessive-compulsive disorder patients(divided into mild,moderate and major group as the condition of the severity of obsessive-compulsive disorder) and 20 healthy controls were scanned with the 3-Dimensional fast low angle shot imaging sequence(3D-FLASH) and SWI.The hippocampal volumes were calculated, the maximum diameter,length and the branching numbers of the inferior ventricular vein clearly demonstrated in the SWIimages were measured.Then the regularity of the changes in the venous system and morphology among the three different severity of obsessive-compulsive disorder and healthy controls were contrastively analyzed. Results: Compared with the control group, the volume of bilateral hippocampus in mild obsessive-compulsive disorder group was not statistically significant(P＞0.05); the volume of bilateral hippocampus in moderate and severe obsessive-compulsive disorder group was significantly lower than that in control group(P＜0.01).Compared with the control group,the number of branches and the diameter of the the lateral ventricle vein in the mild obsessive-compulsive disorder group was decreased(P＜0.01), but there was no statistical difference between the number of venous branches(P＞0.05); compared with the control group,the length of the lateral ventricle vein,the maximum diameter and the number of branches in moderate and severe obsessive-compulsive disorder group decreased significantly(P＜0.01 or P＜0.05). Conclusion: The combination of the SWI and morphological measurement may be used to detect the regularity of the changes in hippocampal structure in patients with different severity of obsessive-compulsive disorder. ［Key words］obsessive-compulsive disorder; hippocampal; magnetic resonance imaging
收稿日期: 2017-07-02
作者简介: 许晓杰(1973—)，男，江苏泰兴人，副主任医师，主要从事中枢神经系统的影像学研究。
引用本文:
许晓杰, 卢辉群, 周玮, 叶向阳, 叶波, 蔡杭美. 应用磁共振成像观察首发强迫症患者海马体积及相关静脉的改变[J]. 江苏大学学报:医学版, 2017, 27(06): 500-503,508.
XU Xiao-Jie, Lu-Hui-Qun, Zhou-Wei, Ye-Xiang-Yang, Ye-Bo, Cai-Hang-Mei. Evaluation of hippocampus volume and related venous in first-episode obsessive-compulsive disorder patients by MRI. Journal of Jiangsu University(Medicine Edition), 2017, 27(06): 500-503,508.
2017, Vol. 27 
