Abstract：Objective: To investigate the correlation between microbleeds and white matter lesions in patients with ischemic cerebrovascular disease. Methods: Two hundred patients with ischemic cerebrovascular disease were included in the study and they were examined with magnetic resonance T2 weighted imaging. They were grouped into microbleeds complicated group (90 cases) and simple ischemia group (110 cases). White matter lesions of all patients were scored, and the general data of the two groups were recorded. The incidence and score of white matter lesions were compared. The correlation between microbleeds and white matter lesions in patients with ischemic cerebrovascular disease was analyzed. Results: The proportions of patients with hypertension, diabetes and hyperlipidemia were shown no significant differences between the two groups (P>0.05). The incidence of white matter lesions and score of white matter lesions in microbleeds complicated group were significantly higher than those in simple ischemia group(P<0.05). With the aggravation of high signal of periventricular and deep white matter high signal, the detection rate of microbleeds increased. The number of microbleeds in deep or cortical cerebral was positively correlated with the severity of cerebral white matter lesions (r=0.487, r=0.461) and the severity of cerebral white matter lesions (r=0.390, r=0.371). Conclusion: Cerebral white matter lesions are closely associated with microbleeds in patients with ischemic cerebrovascular disease. The detection rate of microbleeds increases with the aggravation of cerebral white matter lesions, and the number of microbleeds at different sites is positively correlated with the severity of cerebral white matter lesions.
收稿日期: 2017-03-01
作者简介: 陈军(1970—)，女，四川渠县人，副主任医师。
引用本文:
陈军. 缺血性脑血管病微出血与脑白质病变的相关性[J]. 江苏大学学报:医学版, 2017, 27(04): 320-323.
CHEN Jun.
Correlation between microbleeds and white matter lesions in patients with ischemic cerebrovascular disease. Journal of Jiangsu University(Medicine Edition), 2017, 27(04): 320-323.
[1\]罗何婷,董玮,鹿晓君,等. SWI对急性脑梗死并发脑微出血的诊断价值研究\[J\].中国CT和MRI杂志, 2016, 14(10):11-13.\[2\]Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges\[J\]. Lancet Neurol, 2010, 9(7): 689-701.\[3\]任海燕,陈旭.脑微出血与认知功能障碍的相关性研究\[J\]. 中华老年心脑血管病杂志, 2014, 16(3): 280-283.\[4\]闫丙川. 不同类型急性缺血性脑血管病患者脑微出血的差异研究\[J\]. 国际医药卫生导报, 2016, 22(13):1897-1899.\[5\]李婷,张微微. 脑微出血的研究新进展\[J\]. 北京医学, 2015, 37(1):41-43.\[6\]第四届脑血管病学术会议.各类脑血管疾病诊断要点\[J\].中华神经科杂志，1996, 29(6): 379-381.\[7\]Fazekas F, Kleinert R, Offenbacher H, et al. Pathologic correlates of incidental MRI white matter signal hyperintensities\[J\]. Neurology, 1993, 43(9):1683-1689.\[8\]Scheltens P, Barkhof F, Leys D, et al. A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging\[J\]. J Neurol Sci, 1993, 114(1):7-12.\[9\]张楠. 缺血性脑血管病合并脑微出血相关要点及认知机制的临床分析\[J\]. 中国地方病防治杂志, 2014,29(2):385-386.\[10\]卢俏丽, 李晨,尹延英,等.缺血性脑血管病患者脑微出血的危险因素分析\[J\].山东医药, 2015, 55(21):13-16.\[11\]石倩千,曹红元,陈东万,等.脑出血与脑微出血关系的研究\[J\].解放军医药杂志, 2014, 26(3):65-68.\[12\]Yamada S，Saiki M, Satow T, et al. Periventricular and deep white mater leukoaraiosis have a closer association with cerebral microbleeds than age\[J\]. Eur J Neurol, 2012, 19(1)：98-104.\[13\]黄信全.124例缺血性脑血管病患者脑微出血相关危险因素分析\[J\].医学综述,2013,19(8):1510-1511.\[14\]高中宝,赵杏丽,王振福,等.脑微出
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