Association of atrial fibrillation with long R-R intervals with obstructive sleep apnea syndrome
XUE She-liang1, ZHOU Yan-juan2 , ZHUANG Zhi-fang2, CAI Gao-jun1, SHI Gan-wei1 ,WENG Wei-jing1
（1. Department of Cardiology； 2. Department of Pulmonary Disease， the Affiliated Wujin Hospital of Jiangsu University， Changzhou Jiangsu 213002， China）
Abstract：Objective: To study the association of atrial fibrillation (AF) with long RR intervals with obstructive sleep apnea syndrome(OSAS). Methods: A total of 126 AF patients were enrolled and evaluated for Holter and polysomnography examination. All patients were divided into two groups according to whether long RR intervals （more than 2.5 seconds） occurred or not. Results: One hundred and six AF patients were divided into case group(38 cases) and control group (88 cases). There were no statistical significance difference between the age, gender, body mass index(BMI), smoking history, and complications of the 2 groups(P>0.05). The incidence of OSAS in case group was 71.1% (27/38), which was higher than that of the control group ［45.5%（40/88），P<0.05］. Apnea hypopnea index(AHI) was (16.1±12.1) times/h and longest apnea time (20.0±12.3) seconds respectively in case group, which was higher than in control group (P<0.05). Pearson correlation analysis showed that OSAS and AHI were associated with incidences of long RR intervals in atrial fibrillation(P<0.05). Multivariable logistic regression analysis showed that AHI was an independent risk factor for long intervals in atrial fibrillation . Conclusion: There is a high incidence of OSAS in atrial fibrillation patients combination with long RR intervals. A higher AHI value could predict an increase in the incidence of long intervals in atrial fibrillation.
[1\]张澍, 华伟, 黄德嘉, 等. 植入性心脏起搏器治疗—目前认识和建议(2010年修订版) \[J\].中华心律失常学杂志, 2010,14(4):245-259.\[2\]Monahan K, Redline S. Role of obstructive sleep apnea in cardiovascular disease\[J\]. Curr Opin Cardiol, 2011, 26(6):541-547.\[3\]Szymański FM，Platek AE, Karpiński G, et al. Obstructive sleep apnoea in patients with atrial fibrillation: prevalence,determinants and clinical characteristics of patients in Polish population\[J\]. Kardiol Pol,2014,72(8):716-724.\[4\]Gami AS，Pressman G, Caples SM, et al. Association of atrial fibrillation and obstructive sleep apnea\[J\].Circulation, 2004, 110(4):364-367.\[5\]门小茜,汪亚坤, 李静,等. 阻塞性睡眠呼吸暂停综合征患者夜间心律失常的临床特征\[J\]. 中华医学杂志, 2013, 93(46):3655-3658.\[6\]Mehra R, Benjamin EJ, Shahar E, et al. Association of nocturnal arrhythmias with sleepdisordered breathing: The Sleep Heart Health Study\[J\]. Am J Respir Crit Care Med, 2006, 173(8):910-916.\[7\]Daccarett M, Segerson NM, Hamdan AL, et al. Relation of daytime bradyarrhythmias with high risk features of sleep apnea\[J\]. Am J Cardiol, 2008, 101(8):1147-1150.\[8\]Grimm W，Hoffmann J，Menz V. Electrophysiologie evaluation of sinus node function and atrioventricular conduction in patients with prolonged ventricular asystole during obstructive sleep apnea\[J\]. Am J Cardiol, 1996, 77(15):1310-1314.
2017, Vol. 27 
