Abstract：Objective: To study the clinical efficacy and safety of tacrolimus combined with glucocorticoid on IgA nephropathy patients with moderate proteinuria. Methods: Twentyfive patients with IgA nephropathy were enrolled in the study and were randomly divided into two groups：single hormone group, 14 cases were given single glucocorticoid treatment; combined treatment group,11 cases were given tacrolimus combined with glucocorticoid treatment. The changes of 24 h urine protein, aminotransferase, serum creatinine, serum glucose, blood pressure, treatment effects, and side effects were observed and compared between two groups before and 10 d, 1 month, 2 month, 4 month, 6 month after treatment. Results: There were no significant differences between two groups with regard to side effects of treatment; and the effect of tacrolimus combined with glucocorticoid were better than taking glucocorticoid singly on IgA nephropathy. Conclusion: When tacrolimus blood concentration fluctuates at 3.76-4.35 μg/L, it takes effect more quickly on IgA nephropathy patients with moderate proteinuria and has higher clinical remission rate.
收稿日期: 2012-09-02
作者简介: 张俊贤(1981—)，女，山西新绛人，住院医师，主要从事肾小球疾病的研究
引用本文:
张俊贤, 钱建忠. 他可莫司联合小剂量激素治疗IgA肾病效果观察[J]. 江苏大学学报:医学版, 2013, 23(3): 263-.
ZHANG Jun-Xian, Qian-Jian-Zhong. Clinical efficacy of tacrolimus combined with small does of hormone therapy on IgA nephropathy. Journal of Jiangsu University(Medicine Edition), 2013, 23(3): 263-.
2013, Vol. 23 
