Abstract：Objective: To examine the expressions of ET-1,MMP-2 and CD31 in liver cancers, and discuss the significance of their expressions. Methods： SP immunohistochemical staining was used to examine the expressions of ET-1, MMP2 and CD31 in 30 normal liver tissues and 30 liver cancers. Results： The different expressions of ET-1, MMP-2 and MVD in normal liver tissues and liver cancers had a statistically significant difference(P<0.01). The expressions of ET-1, MMP-2 and MVD in liver cancers were positively related to clinical stage and differential(P<0.05).But no statistical differences were found between them with age and sex(P＞0.05). MVD in negative expressions of ET-1, MMP-2 were more lower than in positive groups(P<0.05). Conclusions： The expressions of ET-1, MMP-2, MVD were associated with the degree of liver cancer malignancy.The high expressions of ET-1, MMP-2, MVD were correlated with clinical stages and differential degrees in liver cancers.
收稿日期: 2012-08-21
作者简介: 宋曙（1971—），男，江苏盐城人，副主任医师，硕士，主要从事消化系统肿瘤研究。
引用本文:
宋曙1，胥传海1，王振江2，邵伟伟1. 肝细胞肝癌组织中ET-1、MMP-2、CD31蛋白的表达及意义[J]. 江苏大学学报:医学版, 2012, 22(6): 500-502,506.
SONG Shu1, XU Chuan-hai1, WANG Zheng-jiang2, SHAO Wei-wei1. Expressions of endothelin-1， MMP-2 and CD31 in liver cancer and their significance . Journal of Jiangsu University(Medicine Edition), 2012, 22(6): 500-502,506.
[1] 许良中，杨文涛.免疫组织化学反应结果的判断标准[J]. 中国癌症杂志，1996,6（4）：229-231.[2] Weidner N.Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors[J]. Breast Cancer Res Treat,1995,36(2):169-180.[3] Bagnato A,Rosano L.The endothelin axis in cancer[J].I nt J Biochem Cell Biol,2008,40(8):1443-1451.[4] Rodrigues SL,Baldo MP,Mill JG. Association of waiststature ratio with hypertension and metabolic syndrome: populationbased study[J]. Arq Bras Cardiol,2010,95(2):186-191.[5] Datau EA,Wardhana,Surachmanto EE,et al.Efficacy of nigella sativa on serum free testosterone and metabolic disturbances in central obese male[J]. Acta Med Indones,2010,42(3):130-134.[6] Park SH,Choi SJ,Lee KS,et al.Waist circumference and waist-to-height ratio as predictors of cardiovascular disease risk in Korean adults[J]. Circ J,2009,73(9):1643-1650.[7] Bagnato A, Spinella F, Rosan L.The endothelin axis in cancer: the promise and the challenges of molecularly targeted therapy[J]. Can J Physiol Pharmacol,2008,86(8):473-484.[8] Bagnato A, Rosan L.The endothelin axis in cancer[J].I nt J Biochem Cell Biol,2008, 40(8):1443-1451.[9] Cox D,Brennann M,Moran N.Integrins as therapeutic targets: lessons and opportunities[J]. Nat Rev Drug Discov,2010,9(10):804-820.[10] Rathinam R,Alahati SK.Important role of integrins in the cancer biology[J]. Cancer Metastasis Rev,2010,29(1):223-237.
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