Association between different impaired glucose regulation and the earlystage arteriosclerosis
ZHAO Jing-1, 2 , Liang-Jun-2, Dou Lian-Jun-2, et al
1.Graduate School， Xuzhou Medical College, Xuzhou Jiangsu 221009； 2.Department of Endocrinology, the Central Hospital of Xuzhou, Xuzhou Jiangsu 221009,China
Abstract：Objective: To explore the associations of glucose exposure and carotidtofemoral pulse wave velocity (c-f PWV) in prediabetes adults. Methods: Fasting plasma glucose, 2hour oral glucose tolerance test (2h OGTT), hemoglobin A1c(HbA1c) and c-f PWV were analysed in 5 098 non-diabetes subjects. Results: We found that the differences in c-f PWV between individuals with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), high HbA1c and those without these abnormalities were 0.97 m/s, 1.08 m/s and 0.92 m/s (P<0.01). In addition, our data indicated that individuals of both high HbA1c and IFG or IGT had significantly higher levels of c-f PWV compared with those who only had high HbA1c (P=0.036 and 0.03, respectively); or those only had IFG (P=0.02); or only had IGT (P=0.04). Conclusion: c-f PWV was associated with prediabetes, independent of metabolic risk factors. We found that individuals of both high HbA1c and IFG or IGT had additive effects on cf PWV, and all these alterations may contribute to development and progression of atherosclerosis.
2012, Vol. 22 
