Abstract:Objective: To find out the optimum water extraction process for the preparation of Shenyanxiaobai granules. Methods: During the study orthogonal test was used to find out the optimum extraction process of Shenyanxiaobai granules,with weights of total dissolved solids and Astragaloside IV content taken as targets,then medium enlarge test was studied. Results: The laboratory method determined the extraction process as follows: Eight times of water and extracting 2 h for 3 times,and the inventory rating was 132 g (1/10 recipe quantity). Meanwhile,the optimum extraction process got by medium enlarge test was 8 times of water and extracting for 3 times. The first and second time extracted 1.5 h,and the last time extracted 1h. The inventory rating was 15.84. Conclusion: There was difference between the extraction processes determined by laboratory study and medium enlarge test.