Abstract:Objective: The effects of the extractive of Borago officinalis on norepinephrine(NE),dopamine and 5-hydroxytryptamine(5-HT)in mouse model of depression with chronic stress were investigated after establishing of chronic stress mouse models of depression; and to discuss its prevention and cure effects and their possible mechanisms. Methods: Established chronic stress mouse models of depression by using singly housed and long-trem unpredictable mild stress(CUMS); and to determine the change of brain monoamine neurotransmitters of chronic stress depression model mice by using enzyme-linked immunosorbent assay(ELISA). Results: The monoamine neurotransmitters(5-HT,NE,dopamine)contents in model mice were significantly less than normal group. The high,medium group of ethanol extractive from Borago officinalis all could increase the contents of 5-HT,NE,dopamine of mice with chronic stress depression;and the low group of ethanol extractive from Borago officinalis approached a raising trend,but no statistical significance. Conclusion: The Borago officinalis can elevate the contents of the 5-HT,NE and dopamine in the brian which were the possible mechanisms of the prevention and cure effect of the Borago officinalis.
刚宏林, 何志一, 刘相辉, 马跃. 玻璃苣醇提物对慢性抑郁模型小鼠脑组织中神经递质的影响[J]. 江苏大学学报:医学版, 2012, 22(2): 101-103.
GANG Hong-Lin, HE Zhi-Yi, LIU Xiang-Hui, MA Yue. Effects of the ethanol extractive of Borago officinalis on neurotransmitter in the brain tissue of mouse model of chronic depression. Journal of Jiangsu University(Medicine Edition), 2012, 22(2): 101-103.
[1] González CA,Sanz JM,Marcos G,et al. Borage consumption as a possible gastric cancer protective factor[J]. Cancer Epidemiol Biomarkers Prev,1993,2(2):157- 158. [2]徐润娴.γ-亚麻酸的药理作用、开发及应用[J].交通医学,2006,20(4):484-486. [3]贾惠岚.玻璃苣水提物对抑郁症小鼠脑内神经递质5-HT、NA、DA的影响[D].黑龙江:黑龙江中医药大学, 2011:25-31. [4] Willner P. Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation[J]. Psychopharmacolgy(Berl),1997,134(4): 319-329. [5]武丽,张丽萍.中医药对抑郁动物模型影响的研究现状[J].广西中医学院学报,2004,7(2):69-72. [6] Coppen A, Shaw DM, Malleson A, Chaynges in 5-hydroxytryptoplan metabolism in depression[J]. Br Psychiatry,1965, 111(470):105-107. [7] Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression: focus on the serotonin transport- er[J].Clin Chem,1994,40(2):288-295. [8]李云辉,胡随瑜,向群辉,等.天松I号对绝望大鼠模型行为及脑组织血浆5-羟色胺及多巴胺的影响[J].湖 南中医学院学报,2002,9(22):13-15. [9] Invernizzi RW, Garattini S. Role of presynaptic alpha2-adrenoceptors in antidepressant action: recent findings from microdialysis studies[J]. Prog Neuropsychopharma- col Biol Psychiatry,2004,28(5):819-827. [10]曹放.抗抑郁药物研究进展[J].世界最新医学信息文摘,2003, 2(6):914-915. [11] Nemeroff CB. The neurobiology of depression[J].Sci Am,1998,278(6):42-49. [12] Kitayama IT,Otani M,Murase S. Degeneration of the locus ceruleus noradrenergic neurons in the stress-induced depression of rats[J].Ann N Y Acad Sci,2008,1148:95 -98. [13] Jay TM,Rocher C,Hotte M,et al. Placticity at hippocampal to prefrontal cortex synapses is impaired by loss of dopamine and stress: importance for psychiatric diseases [J]. Neurotox Res,2004,6(3):233-244. [14] DAquila PS, Collu M, Gessa GL, et al. The role of dopamine in the mechanism of action of antidepressant drugs [J]. Eur J Pharmacol,2000,405(1/3):365-373.