Effect of low concentration of desflurane combined with remifentanil on corrected Q-T interval of ECG during abdominal surgery in elderly patients
SHI Jin-tao 1, JIANG Chen-hui 1, HE Qi-yue 1, WU Jiao-qing 2
（1. Department of Anesthesiology, BNEQ Medical Center, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing Jiangsu 210019; 2. Department of Anesthesiology, Nanjing Pukou Hospital, Nanjing Jiangsu 210031, China)
Abstract：Objective: To observe the effect of low concentration of desflurane combined with remifentanil on the corrected QT interval(QTc) during abdominal surgery in elderly patients with coronary artery disease CAD or high CAD risk. Methods: A total of fifty-eight patients aged 65-85 years with a history of CAD or a high CAD risk were prospectively studied. The patients were scheduled to undergo laparotomy under general anesthesia with an expected duration longer than 1 h. The patients were randomly devided into three groups, experiment group 1(n=20) and experiment group 2(n=19) inhaled 0.8 minimal alveolar concentration(MAC) and 0.6 MAC desflurane respectively, control group(n=19) inhaled no desflurane. The anesthesia induction of the three groups were the same. The QTc, mean arterial pressure(MAP), heart rate(HR), bispectral index(BIS), the electrocardiographic changes and the use of vasoactive agents were recorded before(T0) and after the intubation(T1), before (T2) and 1 h after(T3) the start of the operation, extubation(T4) and 1 h after the operation(T5). Results: Compared with the control group, at T3, the QTc was prolonged, MAP was decreased in experiment group 1(P<0.05); the QTc was prolonged in experiment group 1 and 2 compared to control group at T4, and HR was higher in experiment group 1 than control group(P<0.05); besides these, the three group had no significant differences in QTc, MAP and HR(P>0.05). Conclusion: The anesthesia protocols of 0.6-0.8 MAC of end tidal desflurane concentration combined with remifentanil might be safely applied to elderly patients with CAD or high CAD risk and maintain stable hemodynamic state.
［Key words］the aged; abdominal operation; desflurane; remifentanil; QTc
收稿日期: 2018-03-26
通讯作者:
吴皎卿(通讯作者)，主治医师，E-mail: 5356199@qq.com
作者简介: 石进涛(1986—)，女，河北井陉人，住院医师，主要从事老年患者麻醉的研究；
引用本文:
石进涛1, 江晨辉1, 何绮月1, 吴皎卿2. 低浓度地氟烷复合瑞芬太尼对老年患者腹部手术QTc的影响[J]. 江苏大学学报:医学版, 2008, 28(03): 237-241.
SHI Jin-Tao-1, Jiang-Chen-Hui-1, He-Qi-Yue-1, Wu-Jiao-Qing-2. Effect of low concentration of desflurane combined with remifentanil on corrected Q-T interval of ECG during abdominal surgery in elderly patients. Journal of Jiangsu University(Medicine Edition), 2008, 28(03): 237-241.
2008, Vol. 28 
