Abstract：Objective: To study the expression of the HMCN1 gene in gastric adenocarcinoma,and its potential mechanism in the development of gastric adenocarcinoma, through mining the information of the Cancer Genome Atlas (TCGA) and other related databases. Methods: The RNA data of 289 patients with gastric adenocarcinoma in TCGA database were analyzed online by Cbioportal. With the patient′s survival time information, Kaplan-Meier Curve was used to analyze the relationship between the HMCN1 variation and the survival of the patients with gastric adenocarcinoma.The information of GEPIA database was used to search for the difference in HMCN1 expression between normal tissues and tumor tissues, and explore their expression in different pathological stages. The Genecards database was used to collect the related protein of HMCN1 gene and the network diagram of HMCN1 related protein was drawn. The related proteins were enriched and analysed the signal pathway, physiological process and the key downstream proteins. Results: In 289 cases of gastric adenocarcinoma, 66 cases(23%) had HMCN1 gene mutation; the total survival time of the HMCN1 variant group was longer than that of the non-variant group(P=0.015 3), but there was no significant difference in the disease-free survival time between the variant group and the non-variant group(P=0.052 3). There were 25 proteins related to HMCN1, such as CTDSPL, DDX1, CLP1 and CFB, among which the expression of CTDSPL protein was reduced in gastric adenocarcinoma, and the accumulation and analysis of related proteins might be involved in the cellular tissue and physiological activities of Wnt signaling pathway, Hippo signaling pathway, serine type endopeptidase activity and so on. Conclusion: HMCN1 was highly expressed in gastric adenocarcinoma tissues, which might play a role in tumor suppressor gene by promoting CTDSPL protein degradation.
［Key words］HMCN1; gastric adenocarcinoma; gene mutation; mechanism
收稿日期: 2018-03-19
通讯作者:
党胜春(通讯作者)，主任医师，E-mail：dscgu@163.com
作者简介: 陈思澈(1992—)，男，硕士研究生
引用本文:
陈思澈, 党胜春, 张建新, 钱小宝, 任天宇, 孙明明. 应用肿瘤数据库信息分析HMCN1基因在胃腺癌中的表达及其作用机制[J]. 江苏大学学报:医学版, 2008, 28(03): 242-245.
CHEN Si-Che, Dang-Sheng-Chun, Zhang-Jian-Xin, Qian-Xiao-Bao, Ren-Tian-Yu, Sun-Ming-Ming. Application of tumor database information to analyze the expression and its potential mechanism of HMCN1 gene in gastric adenocarcinoma. Journal of Jiangsu University(Medicine Edition), 2008, 28(03): 242-245.
2008, Vol. 28 
