As one of the most biologically diverse country in the world, South Africa pays special attention to the establishment, implementation and completion of the legal system of access to and benefitsharing of biological genetic resource. So far it has established a legal system consisting of the Constitution (1996), National Environment Management Act (1998), National Environment Management Act: Biodiversity Act (2004) and Regulations on Bioprospecting, Access and Benefitsharing (2008 and 2015 amendment version). It has set an example of legislation in the field of biological diversity for the World not only in the framework and system, but also in the implementation. Its legal system of biological resource access and benefitsharing focused on the Bioprospecting, features “regulate by steps”, “guaranteed by double contracts”, “emphasis on the administrative licensing”, “multiple participants” etc. These features lead to the booming of South African bioprospecting. Based on the achievement and experience of South Africa, China should borrow its management mode of “regulate by steps”, introduce its idea and practice of “administrative licensing”, pay attention to benefitsharing and improve the information disclosure in such field of legislation in the legislation of biological resource access and control.