Objective  To explore the safety of radiofrequency catheter ablation in patients with atrial fibrillation (AF) and a history of tumor. Methods  We collected the clinical data of 269 AF patients who had undergone radiofrequency ablation. Among the enrolled patients, those non-valvular AF patients with a history of tumor were labeled as the tumor group (16 cases) while those without a history of tumor were divided into the non-tumor group (253 cases).   The clinical characteristics and incidences of peripheral complications were compared between the two groups.  Results  The top three previous tumors are separately gastrointestinal tract tumor (37.50%), gynecology tumor (25.00%), and lung tumor (18.75%). There is no significant difference in the incidence of peripheral complications between the two groups. During  12-month follow-up, the  recurrence rate of  AF between the two groups also does not vary significantly.  Conclusion  In AF patients with a history of tumor, the incidence of complications during perioperative period of catheter ablation is similar to that of AF patients without tumor history, so is the postoperative recurrence rate of AF. Radiofrequency ablation could be used as one of the treatment options for such patients.