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| New understandings about electrocardiographic mechanism of Brugada wave |
| LI Han, ZHONG Guoqiang |
| (1. Department of Cardiology, Liuzhou People’s Hospital, Liuzhou Guangxi 545006; 2. Clinical Medical College, the First Affiliated Hospital of Guangxi Medical University, Guilin Guangxi 530021, China) |
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Abstract Brugada wave is a special ECG pattern that presents as a “triad” of right bundle branch block, STsegment elevation in the right chest lead, and T wave inversion. It could lead to arrhythmia and sudden cardiac death. It has been previously considered that Brugada wave is associated with genetics, electrophysiological mechanism, nerve crest hypothesis and so on. The latest studies have found that mutations in mitochondrial DNA and tRNA, inflammation, and myocardial stroma abnormalities may also be involved in the occurrence and development of Brugada wave. This paper mainly reviews the latest research progress of the electrocardiographic mechanism of Brugada wave.
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