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Abstract Atrial fibrillation (AF) is the most common rapid atrial arrhythmia with high morbidity and mortality in cardiovascular diseases. Its incidence rate increases sharply with age and has become one of the diseases that seriously endanger the health of the population. Current researches on the triggering mechanism of AF mainly focus on abnormal myocardial electrical activity, intracellular ion channel imbalance and autonomic nervous system regulation. However, the triggering mechanism of AF is complicated, and AF is manifested by different pathophysiological processes due to individual differences of patients. This article summarizes the current research progress in the triggering mechanism of AF from six aspects including anatomical mechanism of AF triggers, electrical activity, ion channels, cardiac autonomic nervous system, oxidative stress, and other factors, in order to provide valuable reference for the diagnosis and treatment of AF.
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