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| Relation of CHA2DS2-VASc score to the efficacy of radiofrequency catheter ablation for patients of different sex with paroxysmal atrial fibrillation |
| ZHANG Qi-Yin, ZHANG Jing-Yun, ZENG Xian-Sheng, ZHANG Yu-Zhen, HUI Jie |
| （Department of Cardiology, first Hospital affiliated to Suzhou University，Suzhou Jiangsu 215006，China） |
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Abstract Objective To investigate the correlation betweenCHA2DS2-VASc score and recurrence of paroxysmal atrial fibrillation(PAF) after radiofrequency catheter ablation(RFCA) and examining the prognostic value of CHA2DS2-VASc score for recurrence of PAF in patients of different sexes after radiofrequency catheter ablation. [WTHZ]Methods[WT]One hundred and two patients diagnosed with PAF were analyzed in this study. Patients were categorized into two groups that were male group and female group. Recurrence of PAF were confirmed by electrocardiogram or dynamic electrocardiogram through regular followup. Multivariate Cox proportional hazards as performed to examine the relationship between CHA2DS2-VASc score and the recurrence of PAF. KaplanMeier estimation with a Logrank test was used for analysis of the influence of different sexes on recurrence of PAF and comparison of the accuracy, sensitivity, specificity, positive and negative predictive value of predicting AF recurrence when CHA2DS2-VASc score = 2 or 3. Results After a mean followup of twelve months, atrial fibrillation recurrence rate was 28.4%. Following multivariate Cox analysis，CHA2DS2-VASc score was confirmed to be the independent risk factor for recurrence of atrial fibrillation（RR1.896，95% CI 1.3852.596，P＝0.000）.Through multivariate Cox analysis, the recurrence rates of male and female groups were 25.8% and 33.3% , respectively. For male group, the accuracy, sensitivity, specificity, positive and negative predictive value of predicting AF recurrence were 0.637, 0.706, 0.612, 0.387 and 0.857 when CHA2DS2-VASc score = 2,and were 0.742, 0.353, 0.878, 0.500 and 0.796 when CHA2DS2-VASc score = 3. For female group, the accuracy,sensitivity, specificity, positive and negative predictive values of predicting AF recurrence were 0.556, 0.917, 0.375, 0.423 and 0.900 when CHA2DS2-VASc score = 2, and were 0.667, 0.583, 0.708, 0.500 and 0.773 when CHA2DS2-VASc score = 3. Conclusion Increased CHA2DS2-VASc score levels of patients with PAF undergoing RFCA were associated with a higher rate of recurrence of atrial fibrillation. CHA2DS2VASc score =2, both for males and females, as a standard for predicting recurrence has clinical significance.
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2015, Vol. 24 
