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Study on the relationship between heart rate variability and ambulatory blood pressure variability in isolated systolic hypertensives |
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Abstract Objective To investigate the relationship between heart rate variability(HRV) and ambulatory blood pressure variability(BPV) in patients with isolated systolic hypertension(ISH), and to observe the relevance of autonomic nerve functional lesion to ventricular hypertrophy for essental hypertensives. Methods Fifty-seven patients with ISH were enrolled as observation group(including two subgroups:hypertrophy group and non-hypertrophy group) while another 36 individuals with normal blood pressure and without left ventricular hypertrophy as control group. The two groups underwent 24-hour ambulatory electrocardiography(Holter) and 24-hour ambulatory blood pressure monitoring(ABPM) simultaneously, with related HRV and BPV indices recorded.Results The change trends of HRV and BPV were found to be opposite between observation group and control group. That was to say, HRV time domain indices of SDNN, rMSSD and pNN50% in observation group were significantly lower than those of control group while 24 h SSD was significantly higher, both with statistically significant differences(P<0.01). Compared with that of control group, SBP value of hypertrophy group was higher in each time period, while there was no statistically significant difference between DBP value of the two groups. In addition, the incidence of 24-hour ventricular premature beat among hypertrophy group was higher than that in control group, with statistically significant difference(P<0.01).Conclusion The relevant changes of HRV and BPV in patients with isolated systolic hypertension indicate the important role autonomic nerve functional lesion plays in the development of hypertensive left ventricular hypertrophy.
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[1] 中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华心血管病杂志,2011,39(7):579-616.[2] 王岩,唐发宽,周英,等.冠状动脉病变对心率变异性的影响[J].四川医学,2011,32(7):1133-1135.[3] 许伟,徐伯平.老年高血压患者血压昼夜节律变化与心率变异及颈动脉弹性功能的相关性[J].实用老年医学,2008,22(1):33-35.[4] 黄建勇,周覃桃.原发性高血压患者与正常人心率变异性浅析[J].吉林医学,2012,33(27):5841-5842. [5] 张玉凤.原发性高血压患者血压晨峰与心率变异性和心律失常的关系探讨[J].现代中西医结合杂志,2013,22(25):2824-2825.[6] 谢玉华.高血压左室肥厚心率变异的临床观察[J].中国民族民间医药,2012,23(5):13-14.[7] 刘颖,宫海滨.高血压病及高血压心脏病患者血浆中ox-LDL的改变[J].中华全科医学,2013,11(4):506-507.[8] 李新才,曾碧映,邓凤君.福辛普利对原发性高血压患者HRV的影响[J].中国医疗前沿,2013,8(5):43-44.[9] 张溪,牛玲,杨秋萍.自主神经病变诊断方法的临床对比研究[J].临床心电学杂志,2008,17(1):32-33.[10]杨松.心悸患者123例心率变异性分析[J].重庆医学,2006,35(11):1029-1030.[11] 孙焕文,张颖,张向阳,等.老年高血压患者心率变异与颈动脉内膜增厚的相关性分析[J].中国现代医学杂志,2013,23(1):66-70.[12] 陈咏华,缪初升,薛增奇,等.肾实质性高血压和原发性高血压心率变异性对照分析[J].心电学杂志,2010,29(6):476-477. |
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