Abstract:Objective To analyze the relativity between early localization diagnosis of ECG and coronary artery disease of vascular on acute myocardial infarction. Methods A total of 159 cases of ECG characteristics of acute myocardial infarction(the ST-segment and Q wave infarction)were compared with the results of coronary angiography analysis. Results Ninteen cases of ST-segment elevation of V1~V6leads on extensive anterior wall were found which companied with varying leads pathological Q waves appeared,while ST-segment depression of I, aVL,Ⅱ,Ⅲ,aVF leads also appeared,the main pathological change located in the former drop L-branch and branch. Twenty-four cases of ST-segment elevation of V3~V5leads were found on anterior wall with pathological Q waves appeared,the main pathological change located in the former depression artery. Fifteen cases of ST-segment elevation of V4~V6 leads were found on front wall while visible pathological Q wave appeared on V4 and V5 . The main pathological change located in left circumflex artery,followed by left descending artery.Eleven cases of ST- segment elevation of V1~V3 leads were found on anteroseptal while pathologic Q waves appeared on V2,V3 leads with ST segment depression ofⅡ,Ⅲ,aVF appeared,the main pathological change located in the left circumflex artery,followed by the right coronary artery. Forty-three cases of ST-segment elevation ofⅡ,Ⅲ,aVF leads on inferior were found with pathological Q waves,the main pathological change located in the right coronary artery, followed by the left circumflex artery. Thirty-three cases of ST-segment elevation ofⅡ,Ⅲ,aVF lead were found on underside wall,while ST-segment depressing for I, aVL, V1 ,V6 .While the main pathological change located in right coronary artery followed by circumflex artery. Six cases of ST-segment elevation ofⅡ,Ⅲ,aVF, V1 , V2 leads were found on under partitions,while ST-segment depression of V3~V6 leads appeared. ST-segment elevation of I,aVL lead were found on high lateral wall associated with pathological Q waves appeared,while ST-segment depression ofⅡ,Ⅲ, aVF,V5,V6 were found,the main pathological changes located in left-anterior descending branch. ST- segment elevation of V7,V8 were found on the posterior wall,while ST-segment depression of V1,V2,V3R,V 4Rappeared,the main right coronary artery pathological changed,followed by L-branch. All 159 cases of acute myocardial infarction confirmed by coronary angiography were double-vessel or three-vessel disease. Conclusion Coronary anatomy and the characteristics of blood supply have important clinical significance on diagnosis of different ECG leads on acute myocardial infarction. With the development of clinical application of coronary heart disease,deep understanding will be paid for the relationship between correlation leads on infarct region and occlusion artery.