Abstract:Based on the paradigm theory, this paper researches the evolution of the higher education paradigm from the perspective of the Industrial Revolution. The study finds that up to now the evolution of the higher education paradigm has gone through four stages, which are preaching, intellectual training, specialization and multidisciplinary integration. The transformation of the higher education paradigm is influenced by six key factors: educational values, thinking, technology, social environment, the system, and the market. In the era of "Smart+", the new paradigm of higher education is produced under the influence of six key factors: intelligent technology clusters, radically changing social environment, multimind harmonious and sustainable development values, artificial intelligence thinking, the maker system, and the innovation and entrepreneurship market. Based on this, the article builds a new paradigm of digital human interaction and symbiosis with data as the center and multiple digital presence, forming the threetier learner growth flywheel with a positive cycle, so that learners can learn in real time and on demand. This new interactive and symbiotic paradigm of higher education is of great guiding significance to the transformation and upgrading of China′s higher education.