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Journal of Jiangsu University(Medicine Edition)
 
2024 Vol.34 Issue.03
Published 2024-05-20
0
2024 Vol. 34 (03): 0- [Abstract] ( 11 ) [HTML 1KB] [ PDF 1316KB] ( 253 )
185 The effect and possible mechanism of mesenchymal stem cell transplantation on pristane induced pulmonary alveolar hemorrhage in lupus-prone mice
Objective： To investigate the effect of mesenchymal stem cells (MSC) transplantation on pristane induced pulmonary alveolar hemorrhage in lupus mice and explore the possible mechanism. Methods： Twenty female C57BL/6 (B6) mice at 10 weeks of age were injected with 0.5 mL pristane intraperitoneally and 3 control B6 mice were injected with the same volume of PBS. After one week, mice injected with pristane were randomly divided into two groups and intravenously injected with 1×106 human umbilical cord-derived MSCs or PBS, respectively. After another week of observation, the survival rate and body weight of the two groups were recorded and all mice were sacrificed. The appearance of the lungs was observed and hematoxylin and eosin (HE) staining was performed to assess the severity of pulmonary hemorrhage. Lung single-cell suspensions were prepared by enzymatic digestion. CD4+ and CD8+ T lymphocytes, CD19+ B lymphocytes, CD11b+Gr1+ neutrophils, F4/80+ macrophages and CD206+ macrophages in lungs were detected by flow cytometry. Results： The survival rate of mice in the MSC group was higher than that of the PBS group, but the difference was not statistically significant (P=0.07), and the average body weight in MSC mice was significantly increased (P<0.01) than that in PBS group. The incidences of complete diffuse alveolar hemorrhage and partial diffuse alveolar hemorrhage in the MSC group were lower than that in the PBS group. Compared with the PBS mice, the total number of lung cells in the MSC group was significantly reduced (P<0.01) than that in the PBS group. The number of lung CD4+ T cells in the MSC group showed a decreased tendency, while the numbers of CD8+ T cells and CD19+ B cells were significantly decreased (P<0.05) in the MSC group than that in the PBS group. The absolute numbers of CD11b+Gr1+ neutrophils and F4/80+ macrophages in lungs of MSC treated mice were also markedly reduced (P<0.01 and P<0.05). In addition, the percentage of CD206+ anti-inflammatory macrophages in lungs of pulmonary hemorrhage mice was significantly reduced (P<0.01), while the percentage of CD206+ anti-inflammatory macrophages was significantly increased by MSC transplantation (P<0.01). Conclusion： MSC transplantation can significantly reduce the incidence of pulmonary hemorrhage in lupus-prone mice, which may attributed to the regulation of lung immune cells and the induction of CD206 anti-inflammatory macrophages by MSCs.
［Key words］mesenchymal stem cell; systemic lupus erythematosus; alveolar hemorrhage; macrophage; CD206
2024 Vol. 34 (03): 185-189,196 [Abstract] ( 16 ) [HTML 1KB] [ PDF 5720KB] ( 207 )
190 Correlation between triglycerideglucose index and hyperuricemia in systemic lupus erythematosus patients
Objective： To explore the correlation between triglyceride glucose (TyG) index and hyperuricemia (HUA) in patients with systemic lupus erythematosus (SLE). Methods： A retrospective cross-sectional study was conducted on 557 hospitalized SLE patients who were initially treated at Nanjing Drum Tower Hospital. Based on the presence or absence of hyperuricemia,they were divided into the HUA group and the SLE group, and a comparative analysis was performed on clinical data, laboratory indicators, and medication usage between the two groups. Logistic regression, restricted cubic spline, and subgroup analysis were used to evaluate the association between TyG index and hyperuricemia. Additionally, the values of various insulin resistance (IR) metabolic indices in predicting the risk of hyperuricemia in SLE patients were also compared using the area under the receiver operating characteristic curve (ROC). Results： In the HUA group, body mass index, systolic blood pressure, diastolic blood pressure, TyG index, 24 hour urine protein, creatinine, the prevalence of combined hyperlipidemia, and the use of tacrolimus were significantly higher compared to the SLE group. After controlling for confounding factors, binary logistic regression analysis revealed that the risk of developing hyperuricemia in the T3 (≥8.82) group, based on TyG index tertile grouping, was 2.900 times higher than that in the T1 (<8.31) group (95%CI: 1.565-5.371, P<0.05). There was a positive linear correlation between TyG index and the risk of hyperuricemia in SLE patients (P for trend<0.05, P for nonlinearity>0.05). Subgroup analysis further suggested gender and age differences in the association between TyG index and hyperuricemia. ROC curve analysis showed that the area under the curve for predicting the occurrence of hyperuricemia in SLE patients using TyG index,TG/HDL-C ratio, METS-IR, and TyG-BMI were 0.651, 0.656, 0.629, and 0.612, respectively. TyG index and TG/HDL-C had higher predictive values for SLE patients with hyperuricemia. Conclusion： Elevated TyG index is associated with an increased risk of hyperuricemia in SLE patients. As a low-cost and readily available indicator, TyG index may be used to predict the risk of hyperuricemia in patients with SLE.
［Key words］triglyceride glucose index; insulin resistance; hyperuricemia; systemic lupus erythematosus
2024 Vol. 34 (03): 190-196 [Abstract] ( 14 ) [HTML 1KB] [ PDF 4998KB] ( 172 )
197
2024 Vol. 34 (03): 197-202 [Abstract] ( 14 ) [HTML 1KB] [ PDF 8668KB] ( 179 )
203
2024 Vol. 34 (03): 203-210 [Abstract] ( 11 ) [HTML 1KB] [ PDF 5485KB] ( 186 )
211 Clinical efficacy of electroacupuncture on hyperandrogenemia in polycystic ovary syndrome with kidney deficiency and phlegm dampness
Objective： To observe the clinical efficacy of electroacupuncture on hyperandrogenism in patients with polycystic ovary syndrome (PCOS) of kidney deficiency and phlegm dampness. Methods： A total of 68 patients of PCOS with kidney deficiency and phlegm dampness were randomly divided into observation group (34 cases, 2 cases dropped off ) and control group (34 cases, 1 case dropped off). The observation group was treated with electroacupuncture, and the control group was treated with comfort electroacupuncture. The levels of serum testosterone and androstenedione were detected before and 3 months after the intervention, and combined with hairy score, acne score, menstrual status score, biphasic rate of basal body temperature and TCM syndrome score index, the therapeutic effects between the two groups were compared. Results： After 3 months of intervention, the total effective rate of the observation group was better than that of the control group (P<0.01). Compared with the control group, the levels of serum testosterone, androstendione, acne score and menstrual status score in the observation group were significantly decreased (P<0.01), but there was no difference in hirsutism score (P>0.05). Compared with the control group, the biphasic rate of basal body temperature in the observation group was insignificant (P>0.05), after 1 month of intervention. After 2 months of intervention, the observation group was better than the control group, and the difference was statistically significant (P<0.05). After 3 months of intervention, the biphasic rate of basal body temperature in the observation group was significantly higher than the control group (P<0.01). After 3 months of electroacupuncture intervention, the acne score, menstrual status score, serum testosterone and androstendione levels were decreased in the observation group (P<0.05), but there was no significant difference in hirsute score compared with that before intervention (P>0.05). There was no significant difference in hairy score, acne score, menstrual status score, serum testosterone and androstenadione levels in control group after 3 months of placebo electroacupuncture intervention (P>0.05). Conclusion： Electroacupuncture can reduce the levels of serum testosterone and androstenadione, reduce acne score and menstrual condition score, improve biphase ratio of basal body temperature, hyperandrogenemia and clinical symptoms in patients with polycystic ovary syndrome with kidney deficiency and phlegm dampness.
［Key words］acupuncture therapy; electroacupuncture; kidney deficiency and phlegm dampness; polycystic ovary syndrome; hyperandrogenism; clinical efficacy
2024 Vol. 34 (03): 211-215,221 [Abstract] ( 15 ) [HTML 1KB] [ PDF 4133KB] ( 150 )
216
2024 Vol. 34 (03): 216-221 [Abstract] ( 8 ) [HTML 1KB] [ PDF 3657KB] ( 230 )
222
2024 Vol. 34 (03): 222-227 [Abstract] ( 12 ) [HTML 1KB] [ PDF 3696KB] ( 176 )
228 MicroRNA-27a-3p inhibits colorectal cancer cell ferroptosis-induced by Erastin through targeting on SLC7A11
Objective： To explore the regulation and mechanism of microRNA-27a-3p (miR-27a-3p) on ferroptosis of colorectal cancer cell line HT-29 and SW480. Methods： Colorectal cancer cell lines HT-29 and SW480 were treated with 0, 25 and 5 μmol/L Erastin, respectively. Real-time fluorescence quantitative PCR (qRT-PCR) was used to detect the mRNA expression of solute carrier family 7 member 11 (SLC7A11) in each group and the optimal concentration of Erastin was screened. HT-29 and SW480 cells were divided into siControl group, siSLC7A11-1 group and siSLC7A11-2 group, and transfected with control siRNA, siSLC7A11-1 and siSLC7A11-2, respectively. The cells were co-cultured with 5 μmol/L Erastin for 0, 24, 48 and 72 h to detect the cell proliferation activity and the level of malondialdehyde in the cells at different time points. HT-29 and SW480 cells were divided into miR-NC group, miR-27a-3p group and anti-miR-27a-3p group, respectively, and transfected with miR-NC, miR-27a-3 mimics and miR-27a-3p inhibitors, respectively. The mRNA expression level of SLC7A11 was detected by qRT-PCR, and the luciferase reporter gene assay was used to detect the luciferase activity of SLC7A11 3′UTR sequence (SLC7A11-WT) and mutant sequence (SLC7A11-Mut). The cells were co-cultured with 5 μmol/L Erastin for 0, 24, 48 and 72 h, and the cell proliferation activity was detected at different time points, and the intracellular malondialdehyde level was detected. Results： The mRNA expression of SLC7A11 in colorectal cancer HT-29 and SW480 cells was significantly increased with the increase of Erastin concentration (P<0.01). In colorectal cancer HT-29 and SW480 cells, compared with the siControl group, the cell proliferation activity in siSLC7A11-1 and siSLC7A11-2 groups was significantly increased at 48 h and 72 h (P<0.05), with a significant decrease in malondialdehyde levels (P<0.05). Compared with the miR-NC group, cell proliferation activity in miR-27a-3p group was significantly enhanced (P<0.05), while malondialdehyde levels and luciferase activity of SLC7A11-WT group were significantly decreased (P<0.05 or P<0.01), and luciferase activity of SLC7A11-Mut group showed no significant changes(P>0.05); and the cell viability of anti-miR-27a-3p group was significantly decreased (P<0.01), the level of malondialdehyde and the luciferase activity of SLC7A11-WT were significantly increased (P<0.01), and the luciferase activity of SLC7A11-Mut was not significantly changed (P>0.05). Conclusion： miR-27a-3p may regulate Erastin-induced ferroptosis in colorectal cancer cells by targeting the 3′UTR of SLC7A11 mRNA.
［Key words］colorectal cancer; ferroptosis; miR-27a-3p; solute carriers 7A11
2024 Vol. 34 (03): 228-233 [Abstract] ( 7 ) [HTML 1KB] [ PDF 6463KB] ( 195 )
234 Exogenous hydrogen sulfide promotes osteogenic differentiation of senescent BMSCs through Wnt/β-catenin signaling pathway
Objective： To investigate the effect of exogenous hydrogen sulfide donor GYY4137 on the osteogenic ability of D-galactose (D-Gal)induced senescent bone marrow mesenchymal stem cells (BMSCs) and its potential mechanism. Methods： BMSCs senescence was induced by different concentrations of D-Gal. The cell activity was detected by CCK8 method and the degree of cellular senescence was evaluated by β-galactosidase staining to choose the optimal concentration of D-Gal. After treatment with various concentrations of GYY4137, the effects of GYY4137 on the activity of normal BMSCs and senescent BMSCs were detected, and the optimal concentration of GYY4137 was determined. CON group, GYY4137 group, D-Gal group and D-Gal+GYY4137 group were set up, and β-galactosidase staining was performed on BMSCs in each group after corresponding treatment. The mRNA expression of cellular senescence-related genes (P16, P21, P53) and cellular senescencerelated inflammatory factors (IL-6, IL-8, TNF-α) was detected by qRT-PCR. Osteoblastic induction differentiation was performed on cells in each group. mRNA expressions of osteogenic differentiation-related factors alkaline phosphatase (ALP), osteocalcin (OCN), Runt-related transcription factor 2 (RUNX2) and human bone morphogenetic protein 2 (BMP2) were detected by qRT-PCR. The number of calcium nodules formed was detected by alizarin red staining. ALP was detected by ALP staining. The differentially expressed genes of D-Gal group and D-Gal+GYY4137 group were detected by transcriptome sequencing. According to the sequencing results, the differentially expressed genes were verified by qRT-PCR. After the expression of Wnt10b was inhibited by DKK1, the osteogenic differentiation ability of senescent BMSCs in each group was detected. Results： The optimal induction concentration of D-Gal was 30 g/L, and the optimal intervention concentration of GYY4137 was 10 μmol/L. The β-galactosidase content in D-Gal group was significantly increased. The mRNA expression levels of senescence related genes (P16, P21, P53) and senescence related inflammatory factors (IL-6, IL-8, TNF-α) were significantly increased (P<0.05 or P<0.01), and the above cell senescence related indicators were significantly decreased after GYY4137 intervention (P<0.05 or P<0.01). During osteogenic differentiation, the mRNA expressions of ALP, OCN, RUNX2 and BMP2 in D-Gal+GYY4137 group were significantly higher than those in D-Gal group (P<0.05 or P<0.01). The sequencing results showed that there were significant differences in Wnt10b expression in Wnt/βcatenin signaling pathway, and qRT-PCR results showed that GYY4137 increased the expression of Wnt10b and its downstream gene β-catenin in senescent cells (P<0.05 or P<0.01), which was consistent with the sequencing results. The expression of Wnt10b was inhibited by 100 μg/L DKK1, and the mRNA expressions of ALP, OCN, RUNX2 and BMP2 related to osteogenic differentiation of senescent BMSCs treated with GYY4137 were significantly decreased (P<0.05 or P<0.01). Conclusion： GYY4137 can alleviate the D-Gal-induced senescent process of BMSCs, and may promote osteogenic differentiation of senescent BMSCs through Wnt/β-cantenin signaling pathway.
［Key words］bone marrow mesenchymal stem cells; cellular senescence; hydrogen sulfide donor; senile osteoporosis; Wnt/β-catenin signaling pathway
2024 Vol. 34 (03): 234-241 [Abstract] ( 12 ) [HTML 1KB] [ PDF 9847KB] ( 199 )
242 Effect of histone acetylation on asthma susceptibility gene ADAM33 in A549 and BEAS-2B cells
Objective： To evaluate the effects of histone acetylation mediated by sodium butyrate, trichostatin A (TSA) and adenoviral E1A binding protein of 300 kD (P300) on the expression of a disintegrin and metalloproteinase 33 (ADAM33), one of asthma susceptible genes, in human non-small cell lung cancer A549 cells and human bronchial epithelial BEAS-2B cells. Methods： Human non-small cell lung cancer A549 cells and human bronchial epithelial BEAS-2B cells were divided into sodium butyrate control group (double distilled water treatment) and 1, 2.5, 5 mmol/L sodium butyrate groups, TSA control group (0.1% dimethyl sulfoxide treatment) and 0.2, 0.4, 0.8 μmol/L TSA groups, respectively. BEAS-2B cells were divided into P300 control group (transfected with P300 mutant plasmid) and P300 group (transfected with P300 expressing plasmid). These cells were treated respectively according to the groups. The ADAM33 promoter activity was analyzed by dual luciferase reporter method, the expression of ADAM33 mRNA was detected by quantitative real time-PCR (qRT-PCR), and the expression of ADAM33 protein was detected by Western blotting. Results： In human non-small cell lung cancer A549 cells, compared with the control group, ADAM33 promoter activity was significantly decreased in 1 mmol/L sodium butyrate group and 0.2 μmol/L TSA group (P<0.01). In human bronchial epithelial BEAS-2B cells, compared with the control group, the activity of ADAM33 gene promoter, mRNA and protein expression levels was greatly decreased in 1 mmol/L sodium butyrate group and 0.2 μmol/L TSA group (P<0.05 or P<0.01). There was no significant difference in ADAM33 expression when increasing the concentration of sodium butyrate and TSA. In BEAS-2B cells, compared with the control group, the promoter activity, mRNA and protein expression levels of ADAM33 in P300 group were markedly decreased (P<0.05). Conclusion： Sodium butyrate and TSA decreased ADAM33 expression in human non-small cell lung cancer A549 cells and human bronchial epithelial BEAS-2B cells through histone acetylation, while P300 decreased ADAM33 expression in human bronchial epithelial BEAS-2B cells through histone acetylation.
［Key words］asthma; a disintegrin and metalloproteinase 33 (ADAM33); sodium butyrate; trichostatin A; human bronchial epithelial BEAS-2B cells
2024 Vol. 34 (03): 242-247,253 [Abstract] ( 9 ) [HTML 1KB] [ PDF 5192KB] ( 225 )
248 Comparison of therapeutic effect of different types of acupotomies  combined with compound betamethasone injection in  the treatment of trigger finger under ultrasound guidance
Objective： To observe the clinical efficacy and safety of different types of needle knife combined with compound betamethasone injection under ultrasound guidance in the treatment of trigger finger. Methods： A total of 111 patients diagnosed with trigger finger in the Department of Pain Clinic Affiliated Hospital of Jiangsu University from May 2020 to May 2023 were selected as the study objects. The patients were randomly divided into three groups: group Ⅰ (n=36), group Ⅱ(n=37) and group Ⅲ (n=38). Group Ⅰ: ultrasound guidance + compound betamethasone injection alone group, group Ⅱ: ultrasound guidance + compound betamethasone injection + flat mouth needle knife group, group Ⅲ: ultrasound guidance + compound betamethasone injection + V-type needle knife group, the followup period was 6 months. The visual analogue score (VAS), modified Quinnell grade were recorded before treatment (T1), the next day after treatment (T2), 3 weeks after treatment (T3) and 6 months after treatment (T4)，as well as the patient global impression of improvement (PGII) and recurrence rate at 6 months of treatment, operation time, adverse reactions were recorded. Results： ① Comparison of VAS score: At T2 time point, the score of group Ⅱ and group Ⅲ was significantly higher than that of group Ⅰ (P<0.001). The score of group Ⅱ was significantly higher than that of group Ⅲ (P<0.05). At T3 and T4 time points, the scores in group Ⅱ and group Ⅲ were significantly lower than those in group Ⅰ (P<0.05 and P<0.001). There was no significant difference between group Ⅱ and group Ⅲ (P>0.05). ② Comparison of improved Quinnell grading: At T2, T3 and T4 time points, the grade in group Ⅱ and group Ⅲ was significantly lower than that in group Ⅰ (P <0.05 and P<0.001). There was no significant difference in grade between group Ⅱ and group Ⅲ (P>0.05). ③ Comparison of PGII overall improvement scores: The scores of group Ⅱ and group Ⅲ were significantly higher than those of group Ⅰ (P<0.001). There was no significant difference between group Ⅱ and group Ⅲ (P>0.05). ④ Comparison of recurrence rate: It was significantly lower in group Ⅱ and group Ⅲ than that in group Ⅰ (P<0.05), but there was no significant difference between group Ⅱ and group Ⅲ (P>0.05). ⑤ Comparison of operating time: The time of group Ⅱ and group Ⅲ was significantly longer than that of group Ⅰ (P<0.001), and group Ⅱ was significantly longer than group Ⅲ (P<0.05). ⑥ There were no obvious adverse reactions in the three groups. Conclusion： The therapeutic effect of ultrasound-guided needle knife combined with compound betamethasone injection on trigger finger is better than that of compound betamethasone injection alone, and the release effect of V-type needle knife is better than that of flat-mouth needle knife.
［Key words］trigger finger; ultrasonic guidance; general type needle knife; V-shaped needle knife; acupotomy
2024 Vol. 34 (03): 248-253 [Abstract] ( 9 ) [HTML 1KB] [ PDF 5458KB] ( 193 )
254 Effect of calcium polycarbophil combined with reduced dosage of compound electrolyte powder on intestinal preparation
Objective： To explore the efficacy of calcium polycarbophil combined with polyethylene glycol electrolyte powder (PEG) in bowel preparation before colonoscopy. Methods： A total of 225 patients receiving colonoscopy at the Digestive Endoscopy Center of Shanghai Eighth People′s Hospital, from November 2021 to October 2022 were enrolled in the study. The patients were randomly divided into three groups: 4 L-PEG group, 2 L-PEG+calcium polycarbophil group and 4 L-PEG+calcium polycarbophil group, 75 cases in each group. Aronchick score, Boston bowel preparation scale (BBPS) score, detection rate of polyps, adenomas and other lesions, antifoam effect score, patient tolerance rate, willingness to re-accept, and adverse reaction events were recorded and analysed. Results： Compared with 2 L-PEG+calcium polycarbophil group and 4 L-PEG group, Aroncheck score in 4 L-PEG+calcium polycarbophil group was significantly decreased (P<0.05), and total BBPS score, left half, middle and right half colon scores were significantly increased (all P<0.05). There was no difference in the detection rates of adenoma and polyp among the three groups (all P>0.05). The antifoam effect score of 4 L-PEG + calcium polycarbophil group was better than that of 2 L-PEG+calcium polycarbophil group and 4 L-PEG group (P<0.05). The tolerance rate of 2 L-PEG+calcium polycarbophil group was significantly higher than that of 4 L-PEG group (P=0.001). The proportion of reacceptance willingness of 2 L-PEG+calcium polycarbophil group was higher than that of the other two groups (both P<0.012 5). The proportion of abdominal distension in 2 L-PEG+calcium polycarbophil group was greatly lower than that in the other two groups (P<0.01). There were no significant differences in the comparison of nausea, vomiting, abdominal pain, dizziness and headache among 3 groups (P>0.05). Conclusion： The intestinal cleansing effect of calcium polycarbophil combined with PEG was more effective than that of PEG alone, the combination of 2 L-PEG and calcium polycarbophil had the similar intestinal cleansing effect as that of 4 L-PEG, and had better tolerance, higher willingness to reacceptance, less adverse events.
［Key words］colonoscopy; intestinal preparation; compound polyethylene glycol electrolyte powder; calcium polycarbophil
2024 Vol. 34 (03): 254-259 [Abstract] ( 10 ) [HTML 1KB] [ PDF 4001KB] ( 192 )
260 Efficacy of transcutaneous electrical nerve stimulation in preventing the formation of previous cesarean scar defect
Objective： To observe the effect of transcutaneous electrical nerve stimulation (TENS) on preventing the formation of previous cesarean scar defect (PCSD). Methods： A total of 151 primary parturients who delivered with cesarean section in the Fourth Affiliated Hospital of Jiangsu University from February 2021 to November 2021 were randomly divided into uterine body sacral tail group (n=51), uterine horn +uterine body sacral tail group (n=50) and control group (n=50). The control group received routine postpartum care; 2 electrodes were applied to the projection site of uterine body surface and the sacral tail 6 hours after cesarean section in the uterine body sacral tail group, and 4 electrodes were applied to the body surface projection of bilateral uterine horns, the projection site of uterine body surface and the sacral tail 6 hours after cesarean section in the uterine horn+ uterine body sacral tail group, and TENS treatment was performed, 20 min per time, once per day, for 3 consecutive days. The uterine size, number of diverticulum formation and size of diverticulum of the three groups were compared at 6 weeks and 6 months after delivery. Results： There was no significant difference in uterine size (uterine length, width and thickness) among the three groups at 6 weeks and 6 months postpartum (P>0.05), but the uterine size of the three groups at 6 months postpartum was significantly smaller than that at 6 weeks postpartum (P<0.01). At 6 weeks and 6 months postpartum, the PCSD formation rate in the uterine body sacral tail group and uterine horn+uterine body sacral tail group was significantly lower than that in the control group (P<0.05), but there was no statistical significance in the PCSD formation rate between the uterine body sacral tail group and the uterine horn+uterine body sacral tail group (P>0.05). There were no significant differences in the changes of diverticulum (diverticulum width, depth and remaining muscle thickness) among the 3 groups at 6 weeks and 6 months postpartum in PCSD patients (P>0.05). Conclusion： The application of TENS 6 hours after cesarean section significantly reduced the formation of PCSD, and there was no significant difference in the effect of reducing the formation of PCSD by using two electrodes or four electrodes.
［Key words］transcutaneous electrical nerve stimulation; previous cesarean scar defect; cesarean delivery; diverticulum
2024 Vol. 34 (03): 260-265 [Abstract] ( 10 ) [HTML 1KB] [ PDF 3859KB] ( 192 )
266 Differentiation of uterine submucosal fibroids from atypical polypoid adenomyomas based on clinical features and ultrasound imaging
Objective： To investigate the clinical features and the value of transvaginal color Doppler ultrasonography in differentiating uterine submucous myoma from atypical polypoid adenomyoma. Methods： Forty-five patients with uterine submucous myoma and 45 patients with atypical polypoid adenomyoma were selected from the Department of Obstetrics and Gynecology of Anqing Municipal Hospital from August 2019 to August 2022. Clinicopathological parameters of the two group patients
were collected, and the ultrasonic morphological characteristics and hemodynamic indexes of the patients were detected by Hitachi Ascendus color ultrasonic diagnostic instrument. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of hemodynamic indexes in the two groups. Results： Compared with atypical polypoid adenomyoma group, the incidence of anemia and dysmenorrhea in submucous myoma group was significantly increased, and intrauterine occupation was greatly decreased (P<0.05). The κ values of transvaginal color Doppler ultrasonography for submucosal fibroids and atypical polypoid adenomyomas were 0.762 (P<0.05) and 0.433 (P<0.05), respectively. Ultrasound imaging results showed that compared with atypical polypoid adenomyoma group, the proportions of low echo, uniform echo, regular shape and clear boundary in submucosal fibroids group were significantly increased (P<0.05), blood flow grade Ⅱ-Ⅲ in submucosal fibroids group was markedly increased (P<0.05), and blood flow resistance index was significantly decreased (P<0.05). ROC curve showed that the AUC of blood flow grade and blood flow resistance index for predicting atypical polypoid adenomyoma was 0.852 (95%CI: 0.765-0.921, P<0.001) and 0.861 (95%CI: 0.776-0.932, P<0.001), respectively. Conclusion： Compared with patients with atypical polypoid adenomyoma, patients with uterine submucous myoma had significant differences in clinical symptoms such as anemia, dysmenorrhea, intrauterine occupation and imaging characterization of transvaginal color Doppler ultrasonography. Patients with uterine submucous myoma and atypical polypoid adenomyoma could be distinguished by both clinical symptoms and transvaginal color Doppler ultrasonography.
［Key words］uterus myoma; endometrial atypical polypoid adenomyoma; clinical features; ultrasonic imaging
2024 Vol. 34 (03): 266-270 [Abstract] ( 10 ) [HTML 1KB] [ PDF 3624KB] ( 175 )
271
2024 Vol. 34 (03): 271-276 [Abstract] ( 7 ) [HTML 1KB] [ PDF 5396KB] ( 192 )
江苏大学学报:医学版
　

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