乳腺癌组织褪黑素受体1和雌激素受体表达的相关性及其临床意义

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Abstract Objective: To discuss the correlation of expression level between melatonin receptor 1(MT1) and estrogen receptor (ER) in breast cancer tissue and its clinical significance. Methods：The expression of MT1, ER in 90 cases of invasive ductal breast cancer, 34 of intraductal breast cancer, 35 of the tissues near breast carcinoma were detected by immunohistochemical staining. The correlation of their expression were analyzed. Results：The positive rate of ER and MT1 expression in invasive ductal breast cancer and intraductal breast cancer were higher than those in the tissues near breast carcinoma. The difference had statistical significance( P＜0.05). The correlation of ER and MT1 expression was observed with histological grade (P=0.036，P=0.015）, clinical stage (P=0.014，P=0.021) and lymph node metastasis(P=0.014，P=0.006) in 124 cases of breast cancer. The results were statistically significant. Negative correlation was observed between the expression of MT1 and ER in invasive ductal breast cancer and intraductal breast cancer（r=-0.411, P=0.000;r=-0.454, P=0.007）.Conclusion：The expression of MT1 and ER in the breast cancer are correlated with the development and transfer of breast cancer. Combined detecting of their expression can provide experimental basis to be used for the prognostic judgment and targeted therapy of breast cancer.

Received: 11 December 2012

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2013/V23/I1/57

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