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| The correlation between blood chloroform and diabetes and related glycemic and lipid metabolic parameters based on NHANES database#br# |
| LI Jiayi1， LIU Xuekui2， GENG Houfa1,2， LIANG Jun1,2 |
(1. Graduate School of Bengbu Medical College, Bengbu Anhui 233000； 2. Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Jiangsu 221000, China)
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Abstract Objective： To explore the correlation between blood chloroform concentration in the human body and the risk of diabetes, and provide a basis for the prevention and control of diabetes. Methods： The data, extracted from 2017—2018 year of the United States National Health and Nutrition Examination Survey database, was used for the study. After excluding pregnant women, teenagers under 18 years old, participants with missing chloroform concentrations, and incomplete diabetes survey, a total of 622 participants were included for further analysis. The participants were divided into T1 (<0.011 μg/L), T2 (≥0.011, and <0.017 μg/L), and T3 (≥0.017 μg/L) groups based on their blood chloroform concentrations using the quartile method. The logistic regression was used to analyze the incidence rate of diabetes among the three groups, and a cubic spline graph was utilized to demonstrate the correlation between chloroform and the risk of diabetes. Results： The risk of developing diabetes increases with the increasing of chloroform concentration (the T3 group was 1.23 times higher than the T1 group). The results of restricted cubic spline analysis showed that chloroform exposure was positive correlation with fasting blood glucose, homeostatic model assessment of insulin resistance (HOMAIR), which was an index for insulin resistance. Furthermore, partial correlation analysis also indicated that there was a positive correlation between chloroform concentration and both fasting blood glucose levels and HOMAIR. Additionally, the risk of developing diabetes was found to be positively associated with chloroform concentration. In addition, subgroup analysis results also showed that blood chloroform was a risk factor for diabetes. Conclusion： Chloroform exposure is an independent risk factor for diabetes, which can increase insulin resistance and thereby increase the risk of developing diabetes.
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Received: 19 April 2023
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