近红外光响应性复合纳米颗粒介导光热消融与自由基生成用于乳腺癌细胞的联合治疗

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Abstract Objective: To develop novel polydopamine composite nanoparticles and explore its combined inhibition of breast cancer cells. Methods: Novel polydopamine nanoparticles -AIPH@PB NPs） were prepared by one-step oxidation polymerization using serum albumin（BSA）, 2,2-azobis［2（2imidazoline2yl）-propane- dihydrochloride （AIPH） and dopamine （DA） as precursors. The physical and chemical properties were characterized by Malvern particle size analyzer, Xray photoelectron spectroscopy（XPS） and Fourier infrared spectroscopy. Ultravioletvisible spectroscopy was used to characterize its ability to generate alkyl radicals. The photothermal conversion efficiency was characterized by near infrared thermal imager. The 4T1 breast cancer cells were used to verify the effect of tumor suppression in vitro. Results: AIPH@PB NPs with good biocompatibility and a particle size of 165 nm were successfully prepared. Under the irradiation of 808 nm nearinfrared laser, AIPH@PB NPs could convert light energy into heat energy （photothermal conversion efficiency could be as high as 31%）. Meanwhile, local high temperature further induced the decomposition of AIPH to produce a large number of alkyl radicals. The cell experiment results showed that photothermal ablation and the generation of alkyl radicals mediated by AIPH@PB NPs significantly reduced the activity of 4T1 cells. Conclusion: AIPH@PB NPs was successfully prepared and may， with strong photothermal conversion efficiency and highefficiency alkyl radical generation capacity, be used for combined inhibition of breast cancer cells.

Received: 26 February 2021

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	Articles by authors
	ZHANG Jingjing
	XU Lixia
	LIU Suwan
	LIU Jinjing
	DU Fengyi
	ZHANG Lirong

Cite this article:

ZHANG Jingjing,XU Lixia,LIU Suwan等.

Near-infrared light-responsive composite nanoparticles mediated photothermal ablation and free radical generation for combined inhibition of breast cancer cells

[J]. Journal of Jiangsu University(Medicine Edition), 2021, 31(05): 369-373.

URL:

http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2021/V31/I05/369

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