Objective: Layer-by-layer self-assembly was used to modify magnetic tungsten disulfide(mWS₂), thus a stable drug loading platform under physiological conditions was built. It had a targeted drug delivery property and synergistic effect on cancer cells through photo-chemotherapy.  Methods: mWS₂ was prepared by solvothermal method, and then positively charged chitosan and negatively charged sodium carboxymethyl cellulose were layer-by-layer deposited in the water system respectively to prepare chitosan/carboxymethyl cellulose sodium modified magnetic tungsten disulfide composite material (mWS₂-CS/CMC). Series of structural characterizations was performed on the synthesized materials and, and its photothermal properties as well as its drug loading and release behavior was studied. In addition, in vitro cell photochemotherapy combined treatment plan was designed, at the same time to its cell uptake and cytotoxicity was examined. Results: The synthesized mWS₂-CS/CMC was superparamagnetic with good stability and high drug loading profile. The drug release assay showed a dual response release to pH and NIR. In addition, it has low toxicity and can be taken up by MCF-7 cells, and produce an excellent therapeutic effect on the combination of photo-chemotherapy on cancer cells. Conclusion: The mWS₂-CS/CMC is an excellent drug carrier and can also be used as a photothermal agent for photothermal therapy and combination therapy.

［Key words］WS₂; magnetic nanoparticles; surface modification; layer-by-layer self-assembly; photothermal therapy; combined therapy; drug carrier