|
|
|
| Expression and significance of survivin and Caspase-3 protein in esophageal precancerosis and cancer tissue |
| ZHOU Zheng-bin1, ZHOU Rui1, HUANG Zhen1, CAO Peng2, CHENG Hong-wei1 |
| (1.Department of Gastroenterology,2.Department of Pathology,Taixing People′s Hospital, Taixing Jiangsu 225400,China) |
|
|
|
|
Abstract Objective: To investigate the relationship between the expression of survivin and Caspase-3 protein and the biological behaviors of esophageal precancerosis and cancer tissue. Methods: The expressions of survivin and Caspase-3 proteins in 63 esophageal cancer specimens,86 atypical hyperplasia specimen（include light，moderate and high grade hyperplasia）,and 40 normal esophageal mucous specimens,were investigated with S-P immunohistochemical technique，and their correlation with pathologic characteristic，and clinical stages of esophageal cancer were analyzed. Results: The positive expression rate of survivin protein showed higher trend（rs=0.732，P＜0.01）, while,that of Caspase-3 protein showed lower trend（rs=－0.687，P＜0.05）,from normal esophageal mucous,to light，moderate and high grade hyperplasia ,and to esophageal cancer.In esophageal cancer tissue,the expression of survivin proteins was positively correlated with the lymph node metastasis and clinical stages（P＜0.01）,and that of Caspase3 protein was positively correlated with the degree of differentiation(P＜0.01）. Moreover,there was a negative association between the survivin and Caspase3 protein expression(r=－0.897,P＜0.01). Conclusion: The expression of survivin and Caspase-3 may be significantly related to the occurrence and progression of esophageal carcinoma,and helpful in predicting the biological behavior and prognosis of esophageal cancer.
|
|
Received: 19 May 2014
|
|
|
|
| [1]Yang X,Xiong G,Chen X,et al.Survivin expression in esophageal cancer:correlation with p53 mutations and promoter polymorphism\[J\].Dis Esophagus,2009,22(3):223-230.［2］Deng H, Zhen H, Fu Z, et al. The antagonistic effect between STAT1 and survivin and its clinical significance in gastric cancer\[J\].Oncol Lett,2012,3(1):193-199.［3］Zhu H,Wang Q,Hu C,et al.High expression of survivin predicts poor prognosis in esophageal squamous cell carcinoma following radiotherapy\[J\].Tumour Biol,2011, 32(6):1147-1153.［4］Chiu CW,Nozawa H,Hanahan D.Survival benefit with proapoptoticm olecular and pathologic responses from dual targeting of mammalian target of rapamycin and epidermal growthfactor receptor in a preclinical model of pancreatic neuroendocrine carcinogenesis\[J\].J Clin Oncol,2010,28(29)：4425-4433.［5］Feng YB，Lin DC，Shi ZZ，et al.Overexpression of PLKI is associated with poor survival by inhibiting apoptosis via enhancement of survivin level in esophageal squamons cellcarcinoma\[J\].Int J Cancer,2009,2(3):578-588.［6］周正斌,杨大明,沈琴,等.熊去氧胆酸诱导肝癌细胞株HepG2凋亡及对Survivin、Caspase-3表达的影响\[J\].胃肠病学和肝病学杂志,2006,15（5）:492-496.［7］Takeno S,Yamashita S,Takahashi Y,et al.Survivin expression in esophageal squamous cell carcinoma:its prognostic impact and splice variant expression\[J\].Eur J CardiothoracSurg,2010,37(2):440-445.［8］Schuchert MJ,Luketich JD,Landreneau RJ.Management of esophageal cancer\[J\].Curr Probl Surg,2010,47(11):845-946. |
| [1] |
LIU Xin-yun1, JIANG Xiao-qin1, BAO Jing-jing1, DOU Rong-rong1, LIU Fu-xing1,DAI Gui-hong1, ZHU Xiao-wei1, CHEN Min2, YU Hong1. Expression and significance of UNC-51-like kinase 1 in esophageal carcinoma tissue[J]. Journal of Jiangsu University(Medicine Edition), 2018, 28(06): 521-. |
|
|
|
|
2014, Vol. 24 
