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| Expression and significance of UNC-51-like kinase 1 in esophageal carcinoma tissue |
| LIU Xin-yun 1, JIANG Xiao-qin 1, BAO Jing-jing 1, DOU Rong-rong 1, LIU Fu-xing 1,DAI Gui-hong 1, ZHU Xiao-wei 1, CHEN Min2, YU Hong1 |
| 1. Department of Pathology, 2. Department of Dermatology,Taizhou People's Hospital, Taizhou Jiangsu 225300, China) |
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Abstract Objective: To evaluate the association of UNC-51-like kinase 1 (ULK1) expression with clinicopathological characteristics and survival time in patients with esophageal squamous cell carcinoma (ESCC). Methods: The expression levels of ULK1 in 94 ESCC and 78 paracancerous tissues were examined using immunohistochemical staining. Results: The levels of cytoplasmic ULK1 expression in ESCC tissues were higher than those in paracancerous tissues(P<0.01).ULK1 expression was significantly associated with lymphatic metastasis(P<0.05)．Survival analysis showed that patients with low ULK1 expression had shorter survival time than those with high ULK1 expression(hazard rate=1.754,95%CI 1.022-3.010,P=0.041). Conclusion: ULK1 was aberrantly expressed in ESCC. Patients with low ULK1 expression had shorter survival rate. ULK1 may be a potential prognostic biomarker for ESCC patients.
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Received: 21 May 2018
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WANG Yan, Shi-Ya-Wei, Wu-Chao-Yang, Xu-Gang. [J]. Journal of Jiangsu University(Medicine Edition), 2015, 25(06): 543-. |
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2018, Vol. 28 
