患者的镇静状态对芬太尼诱发呛咳反应的影响

摘要
图/表
参考文献
相关文章 (6)

全文: PDF (725 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的：探讨患者的镇静状态对芬太尼诱发呛咳反应的影响。方法：择期全麻下行妇科手术患者120例,年龄28～55岁,体质量48～76 kg,ASAⅠ～Ⅱ。采用随机数字表法,将患者随机分为两组(n=60):对照组和镇静组。对照组患者不预注咪达唑仑,镇静组患者预注咪达唑仑并逐渐增加剂量使患者达到镇静与警觉评分(改良OAA／S评分)为3分的镇静状态。静脉注射芬太尼3 μg／kg行麻醉诱导,注射时间2 s。记录芬太尼注射后1 min内呛咳反应的发生情况,并根据呛咳次数进行程度分级。结果：对照组和镇静组呛咳反应的发生率分别为75％(45／60)和70％(42／60),两组比较差异无统计学意义(P>0.05)。对照组和镇静组呛咳反应严重程度比较差异无统计学意义(P>0.05)。结论：改良OAA／S评分为3分的镇静状态对芬太尼诱发呛咳反应的发生无影响。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章

关键词 ：芬太尼, 咪达唑仑, 镇静, 咳嗽

Abstract：Objective: To investigate the effects of sedation on fentanyl-induced cough during anesthesia induction. Methods：One hundred and twenty ASA ⅠorⅡ patients, undergoing elective gynecological operations under general anesthesia, were randomly divided into 2 groups(n=60 each):control group and midazolam sedation group. Sedation group received iv injection of midazolam at 4 mg／kg initially and gradually increasing at 1 mg／kg per time until modified OAA／S scored 3. Results：The incidence of cough in control group and sedation group were 75％(45／60) and 70％(42／60)respectively and there was no significant difference(P>0.05). There was no significant difference in the degree of cough between the two groups(P>0.05).Conclusion: Sedation when modified OAA／S scored 3 has no effects on fentanyl-induced cough during anesthesia induction.

收稿日期: 2012-12-22

通讯作者: 邵东华，主任医师，硕士生导师，E-mail: sdonghua@yahoo.cn

作者简介: 吴进（1983—），男，江苏东台人，主治医师，主要从事临床麻醉学研究

引用本文:

吴进, 邵东华, 戴甫成. 患者的镇静状态对芬太尼诱发呛咳反应的影响[J]. 江苏大学学报:医学版, 2013, 23(1): 72-74. WU Jin, SHAO Dong-hua, DAI Fu-cheng. Effects of sedation on fentanyl-induced cough during anesthesia induction. Journal of Jiangsu University(Medicine Edition), 2013, 23(1): 72-74.

链接本文:

http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2013/V23/I1/72

[1] 王磊,姚锦华,朱君健,等. 优化全麻诱导用药预防患者芬太尼呛咳反应的观察［J］.中华医学杂志,2010,90(13):921-923.

［2］徐知菲,黄科昌, 荆丽君,等. 联合麻醉诱导时芬太尼诱发咳嗽相关因素的研究［J］.临床麻醉学杂志,2011,27(9):867-869.

［3］ Hung KC, Chen CW, Lin VC, et al. The effect of pre-emptive use of minimal dose fentanyl on fentanyl-induced coughing［J］. Anaesthesia,2010,65(1):4-7.

［4］张志捷,王珊珊,徐辉. 右美托咪定预防芬太尼引起呛咳反应的临床研究［J］.实用医学杂志,2011,27(4):671-672.

［5］李榕,李勇,徐洁,等.不同剂量的右美托咪定对芬太尼诱发呛咳反应的影响［J］.江苏医药,2012,38(11):1316-1318.

［6］ Yu J, Lu Y, Dong C,et al. Premedication with intravenous dexmedetomidine-midazolam suppresses fentanyl-induced cough［J］.Ir J Med Sci,2012,29.［Epub ahead of print］

［7］ He L, Xu JM, Dai RP. Dexmedetomidine reduces the incidence of fentanyl-induced cough: a double-blind, randomized, and placebo-controlled study［J］.Ups J Med Sci,2012, 117(1):18-21.

［8］ Weinger MB, Chen DY, Lin T, et al. A role for CNS alpha-2 adrenergic receptors in opioid induced muscle rigidity in the rat［J］. Brain Res,1995,669(1):10-18.

［9］ Hung KC. The possible mechanism of clonidine to suppress fentanyl-induced coughing［J］. Acta Anaesthesiol Scand,2009,53(9):1227-1228.

［10］ Lin CS, Sun WZ, Chan WH, et al. Intravenous lidocaine and ephedrine, but not propofol, suppress fentanyl-induced cough［J］. Can J Anaesth,2004,51(7):654-659.

［11］ Tang Q, Qian Y, Zhang Q, et al. Effects of different priming doses of propofol on fentanyl-induced cough during anesthesia induction: a preliminary randomized controlled study［J］.Ups J Med Sci, 2010,115(2):121-124.

［12］ Burburan SM,Xisto DG, Rocco PR.Anaesthetic management in asthma［J］.Minerva Anestesiol, 2007,73(6):357-365.

［13］ Pizov R, Brown RH, Weiss YS, et al. Wheezing during induction of general anesthesia in patients with and without asthma. A randomized, blinded trial［J］. Anesthesiology, 1995, 82(5): 1111-1116.