Abstract:Objective: To investigate the effects of sedation on fentanyl-induced cough during anesthesia induction. Methods:One hundred and twenty ASA ⅠorⅡ patients, undergoing elective gynecological operations under general anesthesia, were randomly divided into 2 groups(n=60 each):control group and midazolam sedation group. Sedation group received iv injection of midazolam at 4 mg/kg initially and gradually increasing at 1 mg/kg per time until modified OAA/S scored 3. Results:The incidence of cough in control group and sedation group were 75%(45/60) and 70%(42/60)respectively and there was no significant difference(P>0.05). There was no significant difference in the degree of cough between the two groups(P>0.05).Conclusion: Sedation when modified OAA/S scored 3 has no effects on fentanyl-induced cough during anesthesia induction.
收稿日期: 2012-12-22
通讯作者:
邵东华,主任医师,硕士生导师,E-mail: sdonghua@yahoo.cn
作者简介: 吴进(1983—),男,江苏东台人,主治医师,主要从事临床麻醉学研究
引用本文:
吴进, 邵东华, 戴甫成. 患者的镇静状态对芬太尼诱发呛咳反应的影响[J]. 江苏大学学报:医学版, 2013, 23(1): 72-74.
WU Jin, SHAO Dong-hua, DAI Fu-cheng. Effects of sedation on fentanyl-induced cough during anesthesia induction. Journal of Jiangsu University(Medicine Edition), 2013, 23(1): 72-74.
[1] 王磊,姚锦华,朱君健,等. 优化全麻诱导用药预防患者芬太尼呛咳反应的观察[J].中华医学杂志,2010,90(13):921-923.[2] 徐知菲,黄科昌, 荆丽君,等. 联合麻醉诱导时芬太尼诱发咳嗽相关因素的研究[J].临床麻醉学杂志,2011,27(9):867-869.[3] Hung KC, Chen CW, Lin VC, et al. The effect of pre-emptive use of minimal dose fentanyl on fentanyl-induced coughing[J]. Anaesthesia,2010,65(1):4-7.[4] 张志捷,王珊珊,徐辉. 右美托咪定预防芬太尼引起呛咳反应的临床研究[J].实用医学杂志,2011,27(4):671-672.[5] 李榕,李勇,徐洁,等.不同剂量的右美托咪定对芬太尼诱发呛咳反应的影响[J].江苏医药,2012,38(11):1316-1318.[6] Yu J, Lu Y, Dong C,et al. Premedication with intravenous dexmedetomidine-midazolam suppresses fentanyl-induced cough[J].Ir J Med Sci,2012,29.[Epub ahead of print][7] He L, Xu JM, Dai RP. Dexmedetomidine reduces the incidence of fentanyl-induced cough: a double-blind, randomized, and placebo-controlled study[J].Ups J Med Sci,2012, 117(1):18-21.[8] Weinger MB, Chen DY, Lin T, et al. A role for CNS alpha-2 adrenergic receptors in opioid induced muscle rigidity in the rat[J]. Brain Res,1995,669(1):10-18.[9] Hung KC. The possible mechanism of clonidine to suppress fentanyl-induced coughing[J]. Acta Anaesthesiol Scand,2009,53(9):1227-1228.[10] Lin CS, Sun WZ, Chan WH, et al. Intravenous lidocaine and ephedrine, but not propofol, suppress fentanyl-induced cough[J]. Can J Anaesth,2004,51(7):654-659.[11] Tang Q, Qian Y, Zhang Q, et al. Effects of different priming doses of propofol on fentanyl-induced cough during anesthesia induction: a preliminary randomized controlled study[J].Ups J Med Sci, 2010,115(2):121-124.[12] Burburan SM,Xisto DG, Rocco PR.Anaesthetic management in asthma[J].Minerva Anestesiol, 2007,73(6):357-365.[13] Pizov R, Brown RH, Weiss YS, et al. Wheezing during induction of general anesthesia in patients with and without asthma. A randomized, blinded trial[J]. Anesthesiology, 1995, 82(5): 1111-1116.