Research on the relationship between body mass index and sleep architecture changes in patients with obstructive sleep apneahypopnea syndrome
YANG Hua1, XI Feng1, DING Yong-jie2, ZHOU Zhi-cai1
1.Department of Respiration, Pudong People′s Hospital of Shanghai, Shanghai 201200; 2.Department of Respiration, Ruijin Hospital of Shanghai, Shanghai 200025, China
Abstract：[Abstract] Objective: To investigate the relationship between body mass index(BMI) and sleep structure in patients with obstructive sleep apneahypopnea syndrome (OSAHS)． Methods： A total of 182 patients were diagnosed by polysomnography(PSG) and divided into 4 groups: snorer, mild, middle and sever．The percentage of sleep stages of non-rapid eye movement and rapid eye movement, apnea-hypopnea index(AHI), BMI and microarousal(MI) were analyzed. Results： There were significant differences in BMI between snorer, mild, middle and sever group, respectively．The percentage of sleep stages(awaking time, S1, S2, S3+S4) also had significant difference in different groups, respectively. The correlation of BMI and AHI, MI and AHI was positive．And there was negative correlation between S3+S4 and AHI． Conclusion： The values of AHI were highly correlated with BMI, high BMI may be involved in the increased severity of OSAHS. Patients with OSAHS had disordered sleep structure, which was significantly associated with the severe degree of the lesion as indicated by AHI．
收稿日期: 2012-09-06
基金资助:
上海市浦东新区卫生局科研基金资助项目（PW2012A-21）
作者简介: 杨华（1977—），男，上海人，主治医师，主要从事慢性阻塞性肺疾患的临床研究。
引用本文:
杨华1，奚峰1，丁永杰2，周志才1. 不同程度阻塞性睡眠呼吸暂停低通气综合征患者体质量指数及睡眠结构分析[J]. 江苏大学学报:医学版, 2012, 22(6): 510-513.
YANG Hua1, XI Feng1, DING Yong-jie2, ZHOU Zhi-cai1. Research on the relationship between body mass index and sleep architecture changes in patients with obstructive sleep apneahypopnea syndrome. Journal of Jiangsu University(Medicine Edition), 2012, 22(6): 510-513.
[1] Krieger J, McNicholas WT, Levy P, et al. Public health and medicolegal implications of sleep aponea[J]．Eur Respir J, 2002, 20(6)：1594-1609.[2] 中华医学会呼吸病学分会睡眠呼吸疾病学组．阻塞性睡眠呼吸暂停低通气综合征诊治指南（草案）[J]．中华结核和呼吸杂志，2002，25(4):195-198.[3] Beebe DW, Groesz L, Wells C, et al．The neuropsychological effects of obstructive sleep apnea: a meta-analysis of norm-referenced and case-controlled data[J]．Sleep，2003，26(3)：298-307. [4] Jongnarangsin K, Chugh A, Good E, et al．Body mass index, obstructive sleep apnea, and outcomes of catheter ablation of atrial fibrillation[J]．J Cardiovasc Electrophysiol, 2008, 19(7)：668-672.[5] Busetto L, Enzi G, Inelmen EM, et al. Obstructive sleep apnea syndrome in morbid obesity: effects of intragastric balloon[J]．Chest, 2005, 128(2)：618-623.[6] Kapsimalis F, Vorouchakis G, Manousaki A, et al．Association of sIeep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea[J]．Lung, 2008，186(4)：209-217.[7] 魏永莉，傅应云．肥胖与睡眠呼吸暂停综合征的关系[J]．实用医学杂志，2009，25(9)：1445-1447.[8] 钟玲，周光耀．阻塞性睡眠呼吸暂停低通气综合征患者睡眠结构研究[J]．西部医学，2011，23(1)：35-38.[9] 张景行，章功良．睡眠-觉醒机制研究概况[J]．中国现代神经疾病杂志，2006，6(1)：11-16 .[10] 童茂荣, 曹鄂洪, Sonia LG, 等. 睡眠呼吸紊乱基础与临床[M]．北京：人民军医出版社，2001：38-49.[11] 李延忠．睡眠呼吸障碍性疾病\[M\]．济南：山东科学技术出版社，2005: 93-94.[12] 严金柱，季晓林，叶华，等．不同程度鼾症患者睡眠结构及醒觉指数分析[J]．临床神经电生理学杂志，2008，17(2)：86-89.[13] Garrigue S, Pépin JL, Defaye P, et al．High prevalence of sleep apnea syndrome in patients with long-term pacing: the European Multicenter Polysomnographic Study[J]．Circulation, 2007, 115(13)：1703-1709.[14] Olson EJ, Park JG, Morgenthaler TI. Obstructive sleep apnea-hypopnea syndrome[J]．Prim Care, 2005, 32(2)：329-359.
2012, Vol. 22 
