Abstract：Objective: To develop a method of establishing rabbit model of paraquatinduced pulmonary fibrosis. Methods: Twentyfive rabbits were divided randomly into the experimental group (n=20) and control group(n=5)．Paraquat (40 mg/kg) was administrated to the animals of the experimental group by stomach lavaging once of paraquat. The rabbits were killed on the day 3，7，14 and 28 after paraquat administration．The rabbits in the control group were treated by stomach lavaging once of physiological saline and killed on the 28th day. The general conditions, macroscopic structure and pathological changes of lung in the rabbits of both groups were examined and analyzed. Results: The manifestation of intoxication was shown at 1 h after paraquat administration, and obvious fibrosis of the lung tissue was observed on the day 28 in the experimental group. Conclusion:A rabbit model of pulmonary fibrosis can be established reliably by stomach lavaging of paraquat．
引用本文:
郭书华, 尹江宁, 任国庆, 蔡华忠. 百草枯一次灌胃构建家兔肺间质纤维化模型[J]. 江苏大学学报:医学版, 2012, 22(4): 320-323.
GUO Shu-Hua, YIN Jiang-Ning, REN Guo-Qing, CAI Hua-Zhong. Establishment of a rabbit model of pulmonary fibrosis induced by stomach lavaging of paraquat. Journal of Jiangsu University(Medicine Edition), 2012, 22(4): 320-323.
2012, Vol. 22 
