Expression of miR-195 and its clinicopathological significance in patients with gastric carcinoma
ZHANG Jie 1, PANG Li-qun 2 , WU Kun 2, QIN Zhen-sheng 2, LIU Hai-yan 3
(1. School of Medicine, Jiangsu University, Zhenjiang Jiangsu 212013； 2. Department of General Surgery, Huai′an First People′s Hospital, Nanjing Medical University, Huai′an Jiangsu 223300； 3. Department of Pathology, Huai′an First People′s Hospital, Nanjing Medical University, Huai′an Jiangsu 223300, China)
Abstract：Objective: To investigate the association between miR-195 expression and clinicopathological features in tissues and plasma of patients with gastric cancer. Methods: Quantitative real-time PCR was used to detect the miR-195 expression levels in tumor tissues and normal gastric tissues of 47 patients with stomach cancer, as well as in plasma of 47 patients with gastric cancer and 10 healthy people, and investigated the association between the miR-195 expression and the clinicopathological features. Results: Compared with the adjacent normal tissues, the cancerous tissues presented down-regulation of miR-195 expression, which was correlated with lymph node metastasis (P<0.05), but not correlated with gender, age, TNM stage, or the degree of tumor differentiation. Compared with the healthy population, the patients with gastric cancer presented down-regulation of miR-195 expression in plasma, which was correlated with lymph node metastasis (P<0.05), and not correlated with gender, age, TNM stage, or the degree of tumor differentiation. The more lymph node metastasis, the lower expression of miR-195 in patients with gastric cancer. Conclusion: The expressions of miR-195 in tissues and plasma of patients with gastric cancer were significantly decreased, which may be correlated with lymph node metastasis.
2016, Vol. 26 
