Abstract：Objective: To determine the effect of low-dose dexamethasone on blood glucose concentrations in thoracic surgery patients during the first 8 hours after administration. Methods：Ninety patients undergoing selective thoracic surgery were divided randomly into three groups: saline group, dexamethasone 5 mg group, and dexamethasone 10 mg group. Before anesthesia induction, dexamethasone 5 mg and 10 mg were injected intravenously in relative group, respectively. Normal saline was given in a group as control. Blood glucose concentrations were measured at baseline (before anesthesia induction) and 1, 3, and 8 hours after administration. The incidence of hyperglycemic events (At any giving time blood glucose concentration>10 mmol/L) was determined. Results：Compared with baseline, blood glucose concentrations in three groups significantly increased at 3 h and 8 h timepoints. But, the blood glucose concentrations did not differ significantly between the groups receiving dexamethasone (either 5 or 10 mg) and those receiving saline at any measurement time. The incidence of hyperglycemic events did not differ in three groups. Conclusions: Administration of low-dose dexamethasone before anesthesia induction did not influence blood glucose level in thoracic surgery patients during the first 8 hours after administration.
\[1\]Lee HW, Lee H, Chung H,et al. The efficacy of singledose postoperative intravenous dexamethasone for pain relief after endoscopic submucosal dissection for gastric neoplasm\[J\]. Surg Endosc,2014,28(8):2334-2341.\[2\]Burkhardt T, Rotermund R, Schmidt NO, et al. Dexamethasone PONV prophylaxis alters the hypothalamic-pituitary-adrenal axis after transsphenoidal pituitary surgery \[J\]. J Neurosurg Anesthesiol, 2014, 26(3):216-219.\[3\]Eberhart LH, Graf J, Morin AM, et al. Randomised controlled trial of the effect of oral premedication with dexamethasone on hyperglycaemic response to abdominal hysterectomy \[J\]. Eur J Anaesthesiol, 2011, 28(3):195-201.\[4\]Akhtar S, Barash PG, Inzucchi SE. Scientific principles and clinical implications of perioperative glucose regulation and control \[J\]. Anesth Analg, 2010，110(2):478-497.\[5\]Yared JP, Starr NJ, Torres FK, et al. Effects of single dose, postinduction dexamethasone on recovery after cardiac surgery \[J\]. Ann Thorac Surg, 2000,69(5):1420-1424.\[6\]Hans P, Vanthuyne A, Dewandre PY, et al. Blood glucose concentration profile after 10 mg dexamethasone in nondiabetic and type 2 diabetic patients undergoing abdominal surgery \[J\]. Br J Anaesth,2006, 97(2):164-170.\[7\]Joshi GP, Chung F, Vann MA, et al. Society for ambulatory anesthesia consensus statement on perioperative blood glucose management in diabetic patients undergoing ambulatory surgery \[J\]. Anesth Analg,2010,111(6): 1378-1387.\[8\]Moghissi ES, Korytkowski MT, DiNardo M, et al. American association of clinical endocrinologists and American diabetes association consensus statement on inpatient glycemic control \[J\]. Diabetes Care, 2009,32(6): 1119-1131.\[9\]角述兰，陈晴莎，夏赵林. 开颅手术中应用地塞米松对血糖的影响\[J\]. 临床医学，2010，30（5）：90-91.\[10\]王晓霞，黄太满，施明美, 等. 全麻诱导前静脉注射地塞米松对血糖及单核细胞功能的影响\[J\].江苏医药, 2013, 39（14）：1646-1648.
2014, Vol. 24 
