\[1\]Korkhov VM, Sachse C, Short JM, et al. Threedimensional structure of TspO by electron cryomicroscopy of helical crystals\[J\]. Structure, 2010, 18(6): 677-687.\[2\]赵悦,左萍萍,郎森阳.TSPO：外周型苯二氮卓类受体的新命名及其在中枢神经系统中的作用\[J\]. 中国药理学通报, 2010, 26（4）: 432-435.\[3\]Papadopoulos V, Lecanu L. Translocator protein(18 kDa) TSPO: an emerging therapeutic target in neurotrauma\[J\]. Exp Neurol, 2009, 219(1): 53-57.\[4\]仇志坤,徐江平,李云峰.转位蛋白18 kDa：未来治疗神经精神疾病的新靶点\[J\]. 中国药理学与毒理学杂志, 2012, 26(3): 368-371.\[5\]Batarseh A, Papadopoulos V. Regulation of translocator protein 18 kDa(TSPO) expression in health and disease states\[J\]. Mol Cell Endocrinol, 2010, 327(1/2): 1-12.\[6\]Folkersma H, Boellaard R, Yaqub M, et al. Widespread and prolonged increase in (R)11CPK11195 binding after traumatic brain injury\[J\]. J Nucl Med, 2011, 52(8): 1235-1239.\[7\]Grossman R, Shohami E, Alexandrovich A, et al. Increase in peripheral benzodiazepine receptors and loss of glutamate NMDA receptors in a mouse model of closed head injury: a quantitative autoradiographic study\[J\]. Neuroimage, 2003, 20(4): 1971-1981.\[8\]Taliani S, Pugliesi I, Da Settimo F. Structural requirements to obtain highly potent and selective 18 kDa Translocator Protein(TSPO) Ligands\[J\]. Curr Top Med Chem, 2011, 11(7): 860-886.\[9\]Politis M, Su P, Piccini P. Imaging of microglia in patients with neurodegenerative disorders\[J\]. Front Pharmacol, 2012, 3: 96.\[10\]Denora N, Laquintana V, Trapani A, et al. New fluorescent probes targeting the mitochondriallocated translocator protein 18 kDa (TSPO) as activated microglia imaging agents\[J\]. Pharm Res, 2011, 28(11): 2820-2832.\[11\]Cao T, Thomas TC, Ziebell JM, et al. Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat\[J\]. Neuroscience, 2012, 225: 65-75.\[12\]Readnower RD, Chavko M, Adeeb S, et al. Increase in bloodbrain barrier permeability, oxidative stress, and activated microglia in a rat model of blastinduced traumatic brain injury\[J\]. J Neurosci Res, 2010, 88(16): 3530-3539.\[13\]Soustiel JF, Vlodavsky E. Improvement of cerebral metabolism mediated by Ro5-4864 is associated with relief of intracranial pressure and mitochondrial protective effect in experimental brain injury\[J\]. Pharm Res, 2011, 28: 2945-2953.\[14\]EkmarkLewn S, Lewn A, Israelsson C, et al. Vimentin and GFAP responses in astrocytes after contusion trauma to the murine brain\[J\]. Restor Neurol Neurosci, 2010, 28(3): 311-321.\[15\]Chen MK, Guilarte TR. Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair\[J\]. Pharmacol Ther, 2008, 118(1): 1-17.\[16\]Manku G, Wang Y, Thuillier R, et al. Developmental expression of the translocator protein 18 kDa(TSPO) in testicular germ cells\[J\]. Curr Mol Med, 2012, 12(4): 467-475.\[17\]Robertson CL, Puskar A, Hoffman GE, et al. Physiologic progesterone reduces mitochondrial dysfunction and hippocampal cell loss after traumatic brain injury in female rats\[J\]. Exp Neurol, 2006, 197(1): 235-243.\[18\]Scarf AM, Auman KM, Kassiou M. Is there any correlation between binding and functional effects at the translocator protein(TSPO)(18 kDa)\[J\]. Curr Mol Med, 2012, 12(4): 387-397.\[19\]Kreisl WC, Fujita M, Fujimura Y, et al. Comparison of \[11C\](R)-PK 11195 and \[11C\]PBR28, two radioligands for translocator protein(18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker\[J\]. Neuroimage, 2010, 49(4): 2924-2932.\[20\]Choi J, Ifuku M, Noda M, et al. Translocator protein(18 kDa)/peripheral benzodiazepine receptor specific ligands induce microglia functions consistent with an activated state\[J\]. Glia, 2011, 59(2): 219-230.\[21\]Mills C, Makwana M, Wallace A. Ro54864 promotes neonatal motor neuron survival and nerve regeneration in adult rats\[J\]. Eur J Neurosci, 2008, 27(4): 937-946.\[22\]Soustiel JF, Zaaroor M, Vlodavsky E, et al. Neuroprotective effect of Ro54864 following brain injury\[J\]. Exp Neurol, 2008, 214(2): 201-208.\[23\]Veenman L, Gavish M. The role of 18 kDa mitochondrial translocator protein(TSPO) in programmed cell death, and effects of steroids on TSPO expression\[J\]. Curr Mol Med, 2012, 12(4): 398-412.
2014, Vol. 24 
