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| Analysis of arrhythmia events and clinical characteristics in patients with Brugada syndrome |
| CHEN Si-mei, WU Yue-ping |
| Department of Cardiovascular Function，the Affiliated Zhongshan Hospital of Xiamen University, Xiamen Fujian 361004,China |
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Abstract Objective To explore the occurrence and clinical characteristics of arrhythmia events in patients with Brugada syndrome（Brs）by Holter, implantable cardioverter defibrillater(ICD) and combined with the clinical situation. Methods Clinical features of 12 inpatients with Brs,who had been diagnosed in recent 5 years,were observed by following up.All patients were undergone Holter examination to analyze the clinical characteristics of arrhythmia events .According to the follow-up data by ICD, the time characteristics of episodes of ventricular fibrillation were analyzed. Results Holter examination showed that the total number of premature ventricular contraction(PVC) in 8 patients was 0-80/day. The other 4 patients had frequent PVCs and nonsustained ventricular tachycardia, mainly occurring from night to early morning(among them, 1 patient with paroxysmal atrial fibrillation, and 1 patient with frequent atrial premature contraction and atrial tachycardia while in night with a junction escape rhythm ). During a followup period of 6-50 months in 9 patients with implantation of ICD，70 episodes of ventricular fibrillation (VF) were documented, among which 92.8% occurred from night to early morning(22:00-07:00). All the 12 patients had syncope episodes；9 patients suffered from ventricular tachycardia/VF during in hospital, 2 patients with family history of sudden death. Two patients suffered from sudden death during follow-up. Conclusion The episodes of ventricular tachycardia /VF were mainly occurred from nocturnal time to early morning in Brs patients. Brs patients combined with atrial arrhythmias and slow arrhythmia had higher incidence rate of ventricular tachycardia and VF. When confirmed Brs patients suffer from palpitation, we should fully study the episodes of arrhythmia and give appropriate treatment.
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Received: 30 January 2013
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2013, Vol. 22 
