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| Analysis of the relationship between blood pressure circadian rhythm abnormalities in preeclampsia pregnant women and perinatal infant outcomes |
| HUANG Jun, JU Wen-dong, XIONG Xiao-ying, CHEN Ang, WU Li-feng |
| HUANG Jun1，JU Wen-dong2，XIONG Xiao-ying3, CHEN Ang1，WU Li-feng2 (1. Department of Cardiac Electrophysiology, 2. Department of Internal Medicine, 3. Obstetrical Department, the Affiliated Zhongshan Boai Hospital of Southern Medical University, Zhongshan Guangdong 528403, China) |
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Abstract Objective To discuss the effect of blood pressure circadian rhythm abnormalities in preeclampsia patients on perinatal infant outcomes. Methods A total of 217 preeclampsia patients in hospital were selected in the research,including 99 cases with mild preeclampsia and 118 cases with severe preeclampsia. Other 57 pregnant women of concurrent hospital delivery were selected as the control group. The ambulatory blood pressure of all patients during day and at night were monitored.All patients were classified by three groups, dipper type, non-dipper type and antidipper type, according to the circadian rhythm of blood pressure. Results The incidence of nondipper type and antidipper type in group of preeclampsia patients was significantly higher than that of the control group (P <0.001).The incidence of various adverse perinatal infant outcomes were higher in patients with anti-dippers type blood pressure. The incidence of adverse perinatal infant outcomes in patients with anti-dipper type were markedly higher compared with patients from dipper and non-dipper type(both P<0.05). Conclusion Circadian rhythm abnormalities adversely affected the outcome of perinatal infants. Therefore, more attention should be focused on anti-dipper type patients. It will be helpful for maternal and infants′ safety by strengthening efforts to reduce nocturnal blood pressure and grasping the timely opportunity to terminate the pregnancy.
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Received: 08 February 2013
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2013, Vol. 22 
