In vitro inhibitive effect of propolis of supercritical CO2 extract on tumor cells
1. School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China; 2. Jiangsu Provincial Research Center of Agricultural Products Bio-processing and Separation Engineering, Zhenjiang, Jiangsu 212013, China）
Abstract：In vitro anti-tumor activity of supercritical CO2 extract of propolis （SE-P） was studied by means of MTT assay and was compared with ethanol extract of propolis from market （ME-P） and 95% ethanol extract of propolis residue after being extracted by supercritical CO2 （RE-P）. Anti-tumor activity of SE-P gained under various extraction pressure was studied. SE-P has an obvious inhibitive effect on U937, 95D, SGC-7901 and TE-1 cell lines. Comparing to ME-P and RE-P, SE-P has the highest anti- tumor activity to above cell lines. The anti-tumor activity factors can be extracted within a wide pressure range. The best ranges are 10 - 15 MPa and 20 - 30 MPa. It shows that the SE-P has obvious anti-tumor activity on tumor cell lines.
马海乐, 毛丽琴, 高寅飞, 骆琳, 王振斌. 蜂胶超临界CO2萃取物的体外抑瘤[J]. 江苏大学学报（自然科学版）, 2008, 29(1): 5-8.
Ma Haile, Mao-Liqin, Gao-Yinfei, Luo Lin, WANG Zhenbin. In vitro inhibitive effect of propolis of supercritical CO2 extract on tumor cells[J]. Journal of Jiangsu University(Natural Science Eidtion)
, 2008, 29(1): 5-8.
2008, Vol. 29 
