精子DNA碎片化指数与体外受精胚胎移植结局的关系

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Abstract Objective: To investigate the relationship between DNA damage of sperm and outcomes of in vitro fertilizationembryo transfer(IVFET). Methods: We selected 90 couples undergoing the IVFET in the reproductive center of Changzhou Women′s and Children′s Healthcare Hospital. These patients were divided into three groups with DFI values 30％ respectively as normal group,lower damage group and higher damage group. The ages of male and female, semen routine parameters of male, number of ova obtained by female, fertilization rates, cleavage rates, good quality embryo rates, blastocyst formation rates, pregnancy rates and abortion rates were collected and calculated, and then we analyzed the differences among the three groups. Results: There was no significant difference in the ages of male and female, semen routine parameters of male, and numbers of ova in the three groups (P>0.05). There was no statistically significant difference in the rates of fertilization and cleavage between the three groups(P>0.05). Compared with normal group (74.34％±21.56％,31.27％±20.54％), the good quality embryo rates(59.65％±28.93％) and blastocyst formation rates(13.49％±17.74％) of higher damage group were significantly decreased(P0.05). Conclusion: High value of DFI may be associated with lower the good quality embryo rates and blastocyst formation rates, as well as the pregnancy rates, but it is not associated with fertilization rates, cleavage rates and abortion rates.

Received: 28 December 2018

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2019/V29/I02/157

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