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| Proportion of myeloidderived suppressor cells in peripheral blood
of patients with lung cancer and its significance
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| PENG Rong-rong1,2, WANG Sheng-jun1 |
| （1. School of Medicine, Jiangsu University, Zhenjiang Jiangsu 212013; 2. Department of Laboratory Medicine, Liyang People′s Hospital, Liyang Jiangsu 213300, China)
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Abstract Objective: To study the changes of the proportion of myeloidderived suppressor cells(MDSCs) in the peripheral blood of patients with lung cancer, and to analyze its relationship with T lymphocyte subsets, and its clinical significance. Methods: A total of 20 healthy people and 30 lung cancer patients were selected and their peripheral blood samples were also collected. In addition, 15 lung cancer patients who were 30 days after operation were selected and their peripheral blood samples were also collected. The proportion of HLADR-CD33+ CD11+MDSCs and the proportion of T lymphocyte subsets in peripheral blood were detected by flow cytometry. The proportion of MDSCs and their correlation with T lymphocyte subsets were analyzed. Results: Compared with healthy controls, the proportion of HLADRˉCD33+CD11+ MDSCs in peripheral blood of patients with lung cancer was significantly increased (P<0.05). The proportion of CD3+T cells, CD4+T cells and CD4+/CD8+ in lung cancer patients were significantly lower than those in healthy controls (P<0.05), while the proportion of CD8+T cells was higher than healthy controls(P<0.05). The level of MDSCs in peripheral blood of patients with lung cancer after operation was lower than that before operation (P<0.05). The proportion of MDSCs in peripheral blood of patients with lymph node metastasis was significantly higher than that without lymph node metastasis (P<0.05). The peripheral blood of patients with lung cancer at stage Ⅲ-Ⅳ was higher than that at stage Ⅰ-Ⅱ(P<0.05). The proportion of MDSCs in peripheral blood of patients with lung cancer was negatively correlated with the proportion of CD4+ T cells(r=-0.524 4,P<0.01), and positively correlated with the proportion of CD8+ T cells(r=0.444 9,P<0.05). Conclusion: The proportion of MDSCs in peripheral blood of patients with lung cancer was increased and correlated with the number of T lymphocyte subsets, which might exert immunosuppressive effect on the organisms.
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2019, Vol. 29 
