脑瘫患儿血清神经元特异性烯醇化酶及髓鞘碱性蛋白浓度的变化及其临床意义

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Abstract Objective: To investigate the changes and clinical significance of serum neuronspecific enolase(NSE) and myelin basic protein(MBP) in children with cerebral palsy. Methods: A total of 46 cases of children with cerebral palsy were selected as observation group，in the same period, 45 cases of sex and age matched healthy children were selected as control group. The serum levels of NSE and MBP in the control group at the time of physical examination and in the observation group before and after 3 months of routine rehabilitation were detected by enzyme linked immunosorbent assay(ELISA). The cerebral palsy Gross Motor Function Classification System(GMFCS) and the Gross Motor Function Measure 88 item(GMFM88) were used to grade and evaluate the gross motor function before and after treatment in the observation group. Results: The serum levels of NSE and MBP in the control group were (6.77±2.08) μg/L and (0.38±0.10) μg/L; the serum levels of NSE and MBP in the observation group before treatment were (16.26±2.94) μg/L and (1.21±0.41) μg/L respectively, and the serum levels of NSE and MBP in the observation group after 3 months of treatment were (13.56±2.29)μg/L and (0.85±0.33)μg/L respectively; the GMFM88 scores of the observation group before and after treatment were (132.33±81.60) and (147.07±83.13) respectively. There was no significant correlation between NSE or MBP levels and age in healthy children of the control group (P>0.05)，and there was a negative correlation between NSE or MBP levels and age before treatment in the observation group (P<0.05). There were significant differences in the levels of NSE or MBP between the control group and the observation group(P<0.05). There was a positive correlation between NSE or MBP levels of the observation group and GMFCS in children with cerebral palsy, and a negative correlation with GMFM88 score (P<0.05). The differences of NSE, MBP and GMFM88 scores in the observation group before and after treatment were statistically significant (P<0.05). Conclusion: Serum NSE and MBP levels in children with cerebral palsy were significantly higher than those in healthy children, and decreased with increasing of age, and correlated with the degree of cerebral palsy and gross motor function.

Received: 31 October 2018

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2019/V29/I01/49

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