胸苷酸合成酶和二氢嘧啶脱氢酶的表达与乳腺癌临床病理特征及预后的相关性

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Abstract Objective: To investigate the expression and clinical significance of thymidylate synthase(TS) and dihydropyrimidine dehydrogenase(DPD) in breast cancer patients in Kashi area. Methods: Immunohistochemical staining was used to compare the expression of TS and DPD in tumor tissues and paracancerous tissues of 60 breast cancer patients. The relationship between the expression of TS and DPD in tumor tissues and clinicopathological features was analyzed. The KaplanMeier method was used to analyze the relationship between expression of TS and DPD protein and survival time of patients. Results: The positive rates of TS and DPD in tumor tissues were significantly higher than those in paracancerous tissues(both P0.05). Conclusion: The expression of TS and DPD in breast cancer tumor tissues was abnormally increased.The expression of TS is associated with some clinicopathological features and survival time of patients.

Received: 12 June 2018

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2018/V28/I05/414

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