尿路上皮癌胚抗原1在卵巢癌组织中的表达及临床意义

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Abstract Objective: To investigate the expression of long noncoding RNA urothelial carcinoembryonic antigen 1(UCA1) in patients with epithelial ovarian cancer(EOC) and its clinical significance. Methods: Ovarian tissue of 30 benign ovarian disease patients and 66 EOC patients were collected. UCA1 expression level was examined by realtime quantitative PCR. The diagnostic value of UCA1 expression was analyzed by ROC curve. The patients with EOC was divided into UCA1high and UCA1low expression group according to ROC method; and the clinicopathological parameters were analyzed. KaplanMeier analysis was used to determine the effect of UCA1 expression on survival time. Results: UCA1 expression of EOC patients was significantly upregulated than that of patients with benign ovarian disease(P<0.05). ROC analysis revealed UCA1 expression could distinguish EOC from benign ovarian disease with the AUC of 0.838(95%CI: 0.749-0.927, P<0.05). Abnormal expression of UCA1 was associated with FIGO stage, tumor differentiation and lymph node metastasis(P<0.05). Patients with highUCA1expression had a significantly shorter overall survival time and diseasefree survival time than patients with lowUCA1expression (P=0.004，0.037, respectively). Conclusion: Overexpression of UCA1 was observed in EOC, and it could be served as a poor prognostic biomarker in EOC.

Received: 14 August 2017

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2018/V28/I01/61

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