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| Correlation between serum levels of testosterone and estradiol and mild cognitive #br# |
| HAN Qingyu1, ZHAO Lin1, LI Juan1, CHEN Xiaopeng2, QIAN Wei1 |
(1. Department of OtolaryngologyHead and Neck Surgery, 2. Department of Neurology, Affiliated People′s Hospital of Jiangsu University, Zhenjiang Jiangsu 212002, China)
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Abstract Objective： To investigate serum testosterone and estradiol levels in male patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and their association with mild cognitive impairment (MCI). Methods： A total of 168 male patients with OSAHS were included and divided into OSAHS with MCI group (85 cases) and OSAHS without MCI group (83 cases). The basic information, sleep breathing monitoring indicators and sex hormone levels between the two groups were compared. The influencing factors of male OSAHS patients with MCI were evaluated by Logistic regression, and ROC curve was drawn to evaluate the corresponding diagnostic values. Pearson correlation analysis was used to evaluate the correlation between serum levels of testosterone and estradiol and serum levels of IL6 and MMP9. Results： There were no significant differences in age, hypertension, diabetes, body mass index (BMI), apnea hypopnea index (AHI), minimum oxygen saturation at night (LSaO2), oxygen drop index and arousal index between the two groups (P>0.05). There were significant differences in smoking and the percentage of SaO2<90% in the total monitoring time (T90) between the two groups (P<0.05). The serum levels of testosterone, estradiol and prolactin in male OSAHS with MCI group were significantly lower than those in male OSAHS without MCI group (P<0.01). Logistic regression analysis showed that T90 was an independent risk factor for male OSAHS with MCI (P<0.01), and serum testosterone and estradiol levels were independent protective factors for OSAHS with MCI in male patients (P<0.01). The area under ROC curve of combined testosterone and estradiol was 0.806, and the sensitivity and specificity were 83.53% and 79.27%, respectively. There was a negative correlation between serum testosterone level and serum IL6 and MMP9 levels (r=-0.683, -0.607, P<0.05); and serum estradiol level was negatively correlated with serum IL6 and MMP9 levels (r=-0.662, -0.615, P<0.05). Conclusion： Decreased serum testosterone and estradiol levels were associated with MCI in male OSAHS patients.
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Received: 13 November 2022
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