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| Influence factors of ultrasoundguided microwave ablation for benign cystic solid thyroid nodules#br# |
| LIU Hongyan1, XU Yongqiang1, LI Xiaolong2, SUN Liping1,2 |
（1. Department of Medical Ultrasound, Bengbu First People′s Hospital, Bengbu Anhui 233000； 2. Department of Medical Ultrasound, Tenth People′s Hospital of Tongji University, Shanghai 200072, China）
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Abstract ［Abstract］Objective： To evaluate the influence factors of ultrasound (US)guided percutaneous microwave ablation (MWA) for benign cystic solid thyroid nodules. Methods： From January 2020 to June 2021, a total of 160 patients with benign cystic solid thyroid nodules were included. All patients underwent USguided percutaneous MWA. Each patient was followed up at the 6month after treatment. According to the nodule volume reduction rate (VRR), VRR≥ 50% was defined as significant effective group (122 cases) and VRR<50% as nonsignificant effective group (38 cases). Univariate analysis and multivariate analysis were used to evaluate the factors influencing the VRR of thyroid nodules. Results： Univariate analysis showed that features such as gender, age, body mass index (BMI), nodule size, maximum nodule diameter, nodule morphology, blood flow, and aspect ration were not significantly associated with VRR<50% (all P>0.05). For nonsignificant effective group, nodules located in the risk triangle, nodules being calcified, and proportion of cystic components＜50% were lower than those in the significant effective group (all P<0.05). Based on multivariate analysis, the features of nodule located in risk triangle（OR=26.076,95% CI: 6.983~97.424,P<0.001） and proportion of cystic components＜50%（OR=18.690,95% CI: 5.412~64.605,P＜0.001）were independent risk factors influencing the effect of MWA on benign cystic solid thyroid nodule. The logistic regression equation was established as follows: M=-3.855+(3.261×nodule located in risk triangle)+(2.928×proportion of cystic components＜50%). The associated sensitivity was 78.9% (30/38), specicity was 95.1% (116/122), accuracy was 91.3% (146/160). Conclusion：USguided percutaneous MWA is an effective and safe technique for the treatment of benign cystic solid thyroid nodules. It can significantly reduce the volume of thyroid nodules. The proximity of nodules to the risk triangle and proportion of cystic components＜50% may affect the efficacy of MWA in the treatment of benign cystic solid thyroid nodules.
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Received: 25 March 2022
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