氨基末端B型脑钠肽前体和降钙素原对急性心肌梗死患者预后评估的应用价值

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Abstract Objective: To explore the application value of Nterminal Btype brain natriuretic peptide （NTproBNP） and procalcitonin （PCT） in the prognostic evaluation of patients with acute myocardial infarction. Methods： A total of 260 patients with acute cardiac infarction and 248 healthy persons were included in this study. Logistic regression analysis and receiver operating characteristic curve （ROC） were used to determine the application value of serum NTproBNP and PCT levels. Results： Serum NTproBNP and PCT levels in acute myocardial infarction patients were higher than those in healthy controls （P<0.01）. Serum NT-proBNP and PCT levels of patients who died of acute cardiac infarction were higher than those of surviving control （P<0.01）. Comparing the independent composition ratio of age and Killip cardiac function classification， the difference was statistically significant （P<0.01）; Logistic multivariate analysis showed that age > 60 years old， Killip cardiac function grade Ⅲ to Ⅳ， serum NT-proBNP level， and serum PCT level were all independent risk factors affecting the death in patients with acute myocardial infarction （P<0.01）. ROC analysis showed that the best cut-off points for serum NT-proBNP and PCT levels were 228.95 ng/L and 1.12 ng/mL， respectively， the sensitivity， specificity and area under the curve （AUC） of the combination of the two were 79.17%， 99.58% and 0.861， respectively， and the specificity and AUC wee the highest （specificity， NT-proBNP： P<0.01， PCT： P<0.01; AUC， NT-proBNP： P<0.01， PCT： P<0.01）. Conclusion： Serum NT-proBNP and PCT levels in patients with acute cardiac infarction are abnormally elevated， and both are independent risk factors for patients death， the combination of the two are more effective in predicting the prognosis of the disease.

Received: 25 January 2021

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	Articles by authors
	XU Fei
	JIANG Ya
	LIANG Jianjun

Cite this article:

XU Fei,JIANG Ya,LIANG Jianjun.

Application value of N-terminal B-type brain natriuretic peptide and procalcitonin in prognostic evaluation of patients with acute cardiac infarction

[J]. Journal of Jiangsu University(Medicine Edition), 2021, 31(04): 345-349.

URL:

http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2021/V31/I04/345

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