[1]Bray F, Ferlay J, Soerjomataram I, et al.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin, 2018, 68(6): 394-424.
[2]Siegel RL, Miller KD, Jemal A.Cancer statistics, 2020[J].CA Cancer J Clin, 2020, 70(1): 7-30.
[3]Arnold M, Sierra MS, Laversanne M, et al.Global patterns and trends in colorectal cancer incidence and mortality[J].Gut, 2017, 66(4): 683-691.
[4]Zellweger M, AbdelnourBerchtold E, Krueger T, et al.Surgical treatment of pulmonary metastasis in colorectal cancer patients: Current practice and results[J].Crit Rev Oncol Hematol, 2018, 127: 105-116.
[5]Yamagishi H, Kuroda H, Imai Y, et al.Molecular pathogenesis of sporadic colorectal cancers[J].Chin J Cancer, 2016, 35: 4.
[6]Robles AI, Traverso G, Zhang M, et al.Wholeexome sequencing analyses of inflammatory bowel diseaseassociated colorectal cancers[J].Gastroenterology,2016, 150(4): 931-943.
[7]Viale PH.The American Cancer Society′s Facts & Figures: 2020 Edition[J].J Adv Pract Oncol, 2020, 11(2): 135-136.
[8]Vatandoust S, Price TJ, Karapetis CS.Colorectal cancer: Metastases to a single organ[J].World J Gastroenterol, 2015, 21(41): 11767-11776.
[9]Xu H, Liu L, Li W, et al.Transcription factors in colorectal cancer: molecular mechanism and therapeutic implications[J].Oncogene,2021, 40(9): 1555-1569.
[10]Ashford TP, Porter KR.Cytoplasmic components in hepatic cell lysosomes[J].J Cell Biol,1962, 12(1): 198-202.
[11]Ameisen JC.On the origin, evolution, and nature of programmed cell death: a timeline of four billion years[J].Cell Death Differ, 2002, 9(4): 367-93.
[12]Lorin S, Hamai A, Mehrpour M, et al.Autophagy regulation and its role in cancer[J].Semin Cancer Biol, 2013, 23(5): 361-379.
[13]White E.Deconvoluting the contextdependent role for autophagy in cancer[J].Nat Rev Cancer, 2012, 12(6): 401-410.
[14]Maiuri MC, Tasdemir E, Criollo A, et al.Control of autophagy by oncogenes and tumor suppressor genes[J].Cell Death Differ, 2009, 16(1): 87-93.
[15]Botti J, DjavaheriMergny M, Pilatte Y, et al.Autophagy signaling and the cogwheels of cancer[J].Autophagy, 2006, 2(2): 67-73.
[16]Lim KH, Staudt LM.Tolllike receptor signaling[J].Cold Spring Harb Perspect Biol, 2013, 5(1): a011247.
[17]Salminen A, Kaarniranta K, Kauppinen A.Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process[J].Ageing Res Rev, 2013, 12(2): 520-534.
[18]Rosenfeldt MT, Ryan KM.The multiple roles of autophagy in cancer[J].Carcinogenesis, 2011, 32(7): 955-963.
[19]Gewirtz DA.The four faces of autophagy: implications for cancer therapy[J].Cancer Res, 2014, 74(3): 647-651.
[20]Panda PK, Mukhopadhyay S, Das DN, et al.Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics[J].Semin Cell Dev Biol, 2015, 39: 43-55.
[21]高利昆, 袁静萍, 洪莉.细胞自噬与肿瘤治疗的研究进展[J].中国组织化学与细胞化学杂志, 2020, 29(2): 183-187.
[22]Wang C, Liang CC, Bian ZC, et al.FIP200 is required for maintenance and differentiation of postnatal neural stem cells[J].Nat Neurosci, 2013, 16(5): 532-542.
[23]Mortensen M, Soilleux EJ, Djordjevic G, et al.The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance[J].J Exp Med, 2011, 208(3): 455-467.
[24]Yamazaki T, BravoSan Pedro JM, Galluzzi L, et al.Autophagy in the cancerimmunity dialogue[J].Adv Drug Deliv Rev, 2021, 169: 40-50.
[25]Galluzzi L, Pietrocola F, BravoSan Pedro JM, et al.Autophagy in malignant transformation and cancer progression[J].EMBO J, 2015, 34(7): 856-880.
[26]Lee HY, Kim J, Quan W, et al.Autophagy deficiency in myeloid cells increases susceptibility to obesityinduced diabetes and experimental colitis[J].Autophagy, 2016, 12(8): 1390-403.
[27]Lucas C, Salesse L, Hoang MHT, et al.Autophagy of intestinal epithelial cells inhibits colorectal carcinogenesis induced by colibactinproducing Escherichia coli in ApcMin/+ mice[J].Gastroenterology, 2020, 158(5): 1373-1388.
[28]Mokarram P, Albokashy M, Zarghooni M, et al.New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets[J].Autophagy, 2017, 13(5): 781-819.
[29]Sakanashi F, Shintani M, Tsuneyoshi M, et al.Apoptosis, necroptosis and autophagy in colorectal cancer: Associations with tumor aggressiveness and p53 status[J].Pathol Res Pract, 2019, 215(7): 152425.
[30]Choi JH, Cho YS, Ko YH, et al.Absence of autophagyrelated proteins expression is associated with poor prognosis in patients with colorectal adenocarcinoma[J].Gastroenterol Res Pract, 2014, 2014: 179586.
[31]Kang MR, Kim MS, Oh JE, et al.Frameshift mutations of autophagyrelated genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability[J].J Pathol, 2009, 217(5): 702-706.
[32]Zhou H, Yuan M, Yu Q, et al.Autophagy regulation and its role in gastric cancer and colorectal cancer[J].Cancer Biomark, 2016, 17(1): 1-10.
[33]An CH, Kim MS, Yoo NJ, et al.Mutational and expressional analyses of ATG5, an autophagyrelated gene, in gastrointestinal cancers[J].Pathol Res Pract, 2011, 207(7): 433-437.
[34]He S, Liang C.Frameshift mutation of UVRAG: Switching a tumor suppressor to an oncogene in colorectal cancer[J].Autophagy, 2015, 11(10): 1939-1940.
[35]Green DR, Levine B.To be or not to be? How selective autophagy and cell death govern cell fate[J].Cell, 2014, 157(1): 65-75.
[36]Guo JY, Chen HY, Mathew R, et al.Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis[J].Genes Dev, 2011, 25(5): 460-470.
[37]Koustas E, Sarantis P, Papavassiliou AG, et al.Upgraded role of autophagy in colorectal carcinomas[J].World J Gastrointest Oncol, 2018, 10(11): 367-369.
[38]QureshiBaig K, Kuhn D, Viry E, et al.Hypoxiainduced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKCEZR(ezrin) pathway[J].Autophagy, 2020, 16(8): 1436-1452.
[39]Alves S, Castro L, Fernandes MS, et al.Colorectal cancerrelated mutant KRAS alleles function as positive regulators of autophagy[J].Oncotarget, 2015, 6(31): 30787-30802.
[40]Gil J, Pesz KA, Sasiadek MM.May autophagy be a novel biomarker and antitumor target in colorectal cancer?[J].Biomark Med, 2016, 10(10): 1081-1094.
[41]Koustas E, Sarantis P, Theoharis S, et al.Autophagyrelated proteins as a prognostic factor of patients with colorectal cancer[J].Am J Clin Oncol, 2019, 42(10): 767-776.
[42]Gil J, Ramsey D, Pawlowski P, et al.The influence of tumor microenvironment on ATG4D gene expression in colorectal cancer patients[J].Med Oncol, 2018, 35(12): 159.
[43]Scherr AL, Jassowicz A, Pato A, et al.Knockdown of Atg7 induces nuclearLC3 dependent apoptosis and augments chemotherapy in colorectal cancer cells[J].Int J Mol Sci, 2020, 21(3):1099.
[44]Han Y, Xue XF, Shen HG, et al.Prognostic significance of Beclin1 expression in colorectal cancer: a metaanalysis[J].Asian Pac J Cancer Prev, 2014, 15(11): 4583-4587.
[45]Cheng X, Feng H, Wu H, et al.Targeting autophagy enhances apatinibinduced apoptosis via endoplasmic reticulum stress for human colorectal cancer[J].Cancer Lett, 2018, 431: 105-114.
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